Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 978618..979243 Replicon chromosome
Accession NZ_CP084740
Organism Dickeya zeae strain A586-S18-A17

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag LHK94_RS04295 Protein ID WP_009114000.1
Coordinates 979040..979243 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2BUK3
Locus tag LHK94_RS04290 Protein ID WP_012883774.1
Coordinates 978618..978986 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK94_RS04275 (LHK94_04280) 974376..977522 + 3147 WP_210181256.1 efflux RND transporter permease subunit -
LHK94_RS04280 (LHK94_04285) 977698..977949 + 252 WP_012883776.1 type B 50S ribosomal protein L31 -
LHK94_RS04285 (LHK94_04290) 977965..978108 + 144 WP_012883775.1 type B 50S ribosomal protein L36 -
LHK94_RS04290 (LHK94_04295) 978618..978986 + 369 WP_012883774.1 Hha toxicity modulator TomB Antitoxin
LHK94_RS04295 (LHK94_04300) 979040..979243 + 204 WP_009114000.1 HHA domain-containing protein Toxin
LHK94_RS04305 (LHK94_04310) 979794..980120 + 327 WP_210181255.1 MGMT family protein -
LHK94_RS04310 (LHK94_04315) 980161..980742 - 582 WP_012883772.1 YbaY family lipoprotein -
LHK94_RS04315 (LHK94_04320) 980960..981823 + 864 WP_012883771.1 acyl-CoA thioesterase II -
LHK94_RS04320 (LHK94_04325) 981947..983239 - 1293 WP_012883770.1 ammonium transporter AmtB -
LHK94_RS04325 (LHK94_04330) 983283..983621 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T219248 WP_009114000.1 NZ_CP084740:979040-979243 [Dickeya zeae]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T219248 NZ_CP116231:c1603905-1603648 [Fusobacterium nucleatum]
ATGTTATTAACTTGGACCGATTTTGCATGGAAACAATATGAAGAGTTACAAGAAAAGGATAAAAGGCTTATAAAGAAGAT
AAATATACTTATTAAGGATATAAAAAGAAATGGAAATGAGGGAATAGGGAAACCAGAGCCTTTACAACATGAACTTAGTG
GTTATTGGAGCAGAAGAATTGATGATAAAAATAGATTAGTCTATAAAGTATCAGATAGTCAAATAATAATAGTTGCTTGT
GCAAATCATTATAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14186.04 Da        Isoelectric Point: 5.1811

>AT219248 WP_012883774.1 NZ_CP084740:978618-978986 [Dickeya zeae]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSVCTVVKT

Download         Length: 369 bp

>AT219248 NZ_CP116231:c1604162-1603905 [Fusobacterium nucleatum]
ATGATAGCAACTAATTATTCTGAAGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACTAAGGACTATGAAACTAT
TATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATATAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAAGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QCC2

References