Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 423942..424559 Replicon chromosome
Accession NZ_CP084740
Organism Dickeya zeae strain A586-S18-A17

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LHK94_RS01950 Protein ID WP_226510965.1
Coordinates 423942..424121 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LHK94_RS01955 Protein ID WP_023639453.1
Coordinates 424149..424559 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK94_RS01930 (LHK94_01935) 419551..420642 - 1092 WP_023639457.1 4-oxalomesaconate tautomerase -
LHK94_RS01935 (LHK94_01940) 420804..421730 + 927 WP_226510962.1 LysR family transcriptional regulator -
LHK94_RS01940 (LHK94_01945) 421892..422959 + 1068 WP_226510963.1 MBL fold metallo-hydrolase -
LHK94_RS01945 (LHK94_01950) 423265..423621 - 357 WP_226510964.1 hypothetical protein -
LHK94_RS01950 (LHK94_01955) 423942..424121 + 180 WP_226510965.1 type II toxin-antitoxin system HicA family toxin Toxin
LHK94_RS01955 (LHK94_01960) 424149..424559 + 411 WP_023639453.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LHK94_RS01960 (LHK94_01965) 424607..425230 - 624 WP_226510966.1 RraA family protein -
LHK94_RS01965 (LHK94_01970) 425227..426072 - 846 WP_226068724.1 ABC transporter ATP-binding protein -
LHK94_RS01970 (LHK94_01975) 426084..427133 - 1050 WP_226510967.1 iron ABC transporter permease -
LHK94_RS01975 (LHK94_01980) 427126..428148 - 1023 WP_226510968.1 iron ABC transporter permease -
LHK94_RS01980 (LHK94_01985) 428145..429062 - 918 WP_226510969.1 iron-siderophore ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6510.62 Da        Isoelectric Point: 10.7838

>T219246 WP_226510965.1 NZ_CP084740:423942-424121 [Dickeya zeae]
MDSRTLIAEIKADGWELVRINGSHHHFIHPAKPGLVTIPHPKKDLPPGTVKSIRKQAGI

Download         Length: 180 bp

>T219246 NZ_CP116224:1274994-1275341 [Actinomyces oris]
ATGCTACGAGGTGAAATCCGCCTTGTCGATTTTGATCCTTCTGTCGGCAGTGAGGCGAACAAGCGTCGACCTGCGCTCAT
AGTGAGTAATGACCATGCCAATGCGGCGGCCGCGCGCCTTGGTCGTGGTATGGTGACAGTGGTCCCATTGACGAGCTCAA
CCTCGCGAGTTCTTCCCTTTCAGGTCTTCCTCCCCTCGGAGGCGACCGGCTTGCCCAAGGACTCCAAGGCTCAGGCGGAG
CAGGTTCGATCGATTGCTGTGGAGAGAGTCGGCGAGGTTGTCGGCTGGTTACCCAGTGGCCTGATGAAAATGGTTAATGA
GGCTCTGATCCAGCATCTCTCCTTGTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14543.59 Da        Isoelectric Point: 4.3391

>AT219246 WP_023639453.1 NZ_CP084740:424149-424559 [Dickeya zeae]
MFYPIAIEAGDDAHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKSPEYIGYTWAV
VDIDVTRLMGGVEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERMSSLR

Download         Length: 411 bp

>AT219246 NZ_CP116224:1274768-1275007 [Actinomyces oris]
ATGAAGTTAAGCGTGAGTTTGTCGGAGAGTGACCTCATTCTGCTGGACCGATGCGTGGAGCGCGACGGTTTGGCGTCGAG
GTCTGCTGGTATTCAGAATGCCATCCGCCTGCTCGGAAAAGCTGATCTTCAGGATGCTTACGCTGAGGCCTGGTCCTCCT
GGGATGCCTCTGAGGATGCAACCGTCTGGGATAGTGCGGTCGCCGACGGGATCGATAGAGGTGAGGATGCTACGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References