Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 4622116..4622783 Replicon chromosome
Accession NZ_CP084736
Organism Gordonia sp. WA4-43

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LEL84_RS20900 Protein ID WP_068970594.1
Coordinates 4622385..4622783 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LEL84_RS20895 Protein ID WP_068970595.1
Coordinates 4622116..4622388 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEL84_RS20880 (LEL84_20880) 4617615..4618598 + 984 WP_226512694.1 LLM class F420-dependent oxidoreductase -
LEL84_RS20885 (LEL84_20885) 4619034..4620200 - 1167 WP_226512695.1 pyridoxal phosphate-dependent aminotransferase -
LEL84_RS20890 (LEL84_20890) 4620298..4621974 + 1677 WP_226512696.1 serine/threonine-protein kinase -
LEL84_RS20895 (LEL84_20895) 4622116..4622388 + 273 WP_068970595.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LEL84_RS20900 (LEL84_20900) 4622385..4622783 + 399 WP_068970594.1 type II toxin-antitoxin system VapC family toxin Toxin
LEL84_RS20905 (LEL84_20905) 4622791..4624467 - 1677 WP_065631752.1 DEAD/DEAH box helicase -
LEL84_RS20910 (LEL84_20910) 4624534..4625463 - 930 WP_068970593.1 oxygenase MpaB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 13906.09 Da        Isoelectric Point: 4.8134

>T219244 WP_068970594.1 NZ_CP084736:4622385-4622783 [Gordonia sp. WA4-43]
MIYLDTSAMVKLVVREAETAPLIEWFALHPGVPTVTSALGRVELMRTALRDGSPGLHERARDLLDALDVIPLSAAVIDIA
ESIGPSSLRSLDALHLASATVIRAEMTAFVAYDQRLTAGASALGYPVVAPGA

Download         Length: 399 bp

>T219244 NZ_CP116223:c3936864-3935551 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGCATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTTTCGATGCCATTACAGCTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGGATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAGAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACAGCA
TTACTTTTAAAAGATAATCATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCCCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9851.23 Da        Isoelectric Point: 8.8319

>AT219244 WP_068970595.1 NZ_CP084736:4622116-4622388 [Gordonia sp. WA4-43]
MRTIGIRELRQHASQYLAQVEAGEELAITNRGRTVARLVPVSAGERSRDALIEAGILVPARRAGGITGLHPETLPTRALT
EVLDQVREDR

Download         Length: 273 bp

>AT219244 NZ_CP116223:c3937122-3936865 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References