Detailed information of TA system TA219243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2566668..2567623
• Replicon: chromosome
• Accession: NZ_CP084736
• Organism: Gordonia sp. WA4-43

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: LEL84_RS11490
• Protein ID: WP_226514125.1
• Coordinates: 2566668..2567243 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: LEL84_RS11495
• Protein ID: WP_137809475.1
• Coordinates: 2567240..2567623 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LEL84_RS11460 (LEL84_11460)	2562545..2562862	-	318	WP_226514121.1	DUF2470 domain-containing protein	-
LEL84_RS11465 (LEL84_11465)	2562855..2562992	-	138	Protein_2259	protein-tyrosine-phosphatase	-
LEL84_RS11470 (LEL84_11470)	2563027..2564172	-	1146	WP_226514296.1	ISL3 family transposase	-
LEL84_RS11475 (LEL84_11475)	2564362..2564973	-	612	WP_226514122.1	tyrosine-protein phosphatase	-
LEL84_RS11480 (LEL84_11480)	2565067..2565699	+	633	WP_226514123.1	flavin reductase family protein	-
LEL84_RS11485 (LEL84_11485)	2565724..2566671	-	948	WP_226514124.1	PfkB family carbohydrate kinase	-
LEL84_RS11490 (LEL84_11490)	2566668..2567243	-	576	WP_226514125.1	zeta toxin family protein	Toxin
LEL84_RS11495 (LEL84_11495)	2567240..2567623	-	384	WP_137809475.1	hypothetical protein	Antitoxin
LEL84_RS11500 (LEL84_11500)	2567747..2568295	-	549	WP_078113765.1	peptide-methionine (S)-S-oxide reductase MsrA	-
LEL84_RS11505 (LEL84_11505)	2568292..2568786	-	495	WP_226514126.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LEL84_RS11510 (LEL84_11510)	2568943..2570058	-	1116	WP_226514127.1	acyl-CoA dehydrogenase family protein	-
LEL84_RS11515 (LEL84_11515)	2570138..2571226	-	1089	WP_226514128.1	VOC family protein	-
LEL84_RS11520 (LEL84_11520)	2571472..2572365	+	894	WP_137809479.1	acetaldehyde dehydrogenase (acetylating)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (2-142)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-70)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21176.26 Da
• Isoelectric Point: 10.1705

>T219243 WP_226514125.1 NZ_CP084736:c2567243-2566668 [Gordonia sp. WA4-43]
VTPRLDLVVGCNGAGKSTLVERHLQPLLHVPFVNADLIARQRWPDSAEAHSYDAARLAAATRDTLIERGTSFIAETVFSH
PSKLELIERAHTAGYRVALHVVMIPEALAVHRVRSRVDSGGHAVPEVKIRERFRRLWPLVRTAIARSDLATVYANERPTT
RIVARYVDGLVAGVPDWPDWTPGALTDTKAR

Nucleotide

• Length: 576 bp

>T219243 NZ_CP116223:c3663744-3663325 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 13709.12 Da
• Isoelectric Point: 4.8093

>AT219243 WP_137809475.1 NZ_CP084736:c2567623-2567240 [Gordonia sp. WA4-43]
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRQRVEAALAGDLPGEVLTAEEAVVYDAEI
DAHLEARLATDDHVDRRAAAGLSSVVVDDAGRLVEYRPDGTSVILEQ

Nucleotide

• Length: 384 bp

>AT219243 NZ_CP116223:c3663974-3663741 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGATAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA