Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 901029..901591 | Replicon | chromosome |
| Accession | NZ_CP084736 | ||
| Organism | Gordonia sp. WA4-43 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A6G7W718 |
| Locus tag | LEL84_RS04165 | Protein ID | WP_055477308.1 |
| Coordinates | 901029..901319 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A6G7W6R5 |
| Locus tag | LEL84_RS04170 | Protein ID | WP_055477309.1 |
| Coordinates | 901316..901591 (-) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LEL84_RS04140 (LEL84_04140) | 896096..896695 | - | 600 | WP_226513397.1 | hypothetical protein | - |
| LEL84_RS04145 (LEL84_04145) | 896980..899040 | + | 2061 | WP_226513398.1 | DEAD/DEAH box helicase family protein | - |
| LEL84_RS04150 (LEL84_04150) | 899075..899314 | + | 240 | WP_055477305.1 | hypothetical protein | - |
| LEL84_RS04155 (LEL84_04155) | 899903..900136 | + | 234 | WP_226513399.1 | hypothetical protein | - |
| LEL84_RS04160 (LEL84_04160) | 900804..901010 | + | 207 | WP_055477311.1 | hypothetical protein | - |
| LEL84_RS04165 (LEL84_04165) | 901029..901319 | - | 291 | WP_055477308.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LEL84_RS04170 (LEL84_04170) | 901316..901591 | - | 276 | WP_055477309.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LEL84_RS04175 (LEL84_04175) | 901711..902331 | - | 621 | WP_223258858.1 | TetR/AcrR family transcriptional regulator | - |
| LEL84_RS04180 (LEL84_04180) | 902328..902855 | - | 528 | WP_065631669.1 | GNAT family N-acetyltransferase | - |
| LEL84_RS04185 (LEL84_04185) | 903263..904024 | + | 762 | WP_139104661.1 | hypothetical protein | - |
| LEL84_RS04190 (LEL84_04190) | 904079..904384 | + | 306 | WP_068970442.1 | hypothetical protein | - |
| LEL84_RS04195 (LEL84_04195) | 904436..904816 | - | 381 | WP_065631666.1 | SRPBCC family protein | - |
| LEL84_RS04200 (LEL84_04200) | 904965..905870 | - | 906 | WP_065631665.1 | RNA polymerase sigma-70 factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 10938.40 Da Isoelectric Point: 9.7360
>T219242 WP_055477308.1 NZ_CP084736:c901319-901029 [Gordonia sp. WA4-43]
MSDAPTDSSAPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAENPHRLSKPLRDDLADLHSARRGDYRILLRIDDPNH
TIVIVRIDHRAHAYRT
MSDAPTDSSAPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAENPHRLSKPLRDDLADLHSARRGDYRILLRIDDPNH
TIVIVRIDHRAHAYRT
Download Length: 291 bp
>T219242 NZ_CP116223:3642757-3643143 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATTGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATTGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 9718.86 Da Isoelectric Point: 4.3809
>AT219242 WP_055477309.1 NZ_CP084736:c901591-901316 [Gordonia sp. WA4-43]
MTTVPLGEAKDKLSALVDSAESTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGVRDDVATADAEYAAGETVSID
DLRAEHGMPPK
MTTVPLGEAKDKLSALVDSAESTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGVRDDVATADAEYAAGETVSID
DLRAEHGMPPK
Download Length: 276 bp
>AT219242 NZ_CP116223:3643136-3643456 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCCGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCCGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6G7W718 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6G7W6R5 |