Detailed information of TA system TA021923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-paaA/-
• Location: 4782621..4783108
• Replicon: chromosome
• Accession: NC_008786
• Organism: Verminephrobacter eiseniae EF01-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A1WQY7
• Locus tag: VEIS_RS20975
• Protein ID: WP_011812030.1
• Coordinates: 4782809..4783108 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: VEIS_RS27075
• Protein ID: WP_011812029.1
• Coordinates: 4782621..4782809 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VEIS_RS20960	4778029..4778667	-	639	WP_011812025.1	LysE family transporter	-
VEIS_RS20965	4778669..4779784	-	1116	WP_011812026.1	alanine racemase	-
VEIS_RS20970	4779995..4781299	+	1305	WP_011812027.1	lysophospholipid transporter LplT	-
VEIS_RS29220	4781342..4781527	+	186	WP_157048621.1	hypothetical protein	-
VEIS_RS29225	4782185..4782346	+	162	WP_157048622.1	hypothetical protein	-
VEIS_RS27075	4782621..4782809	+	189	WP_011812029.1	hypothetical protein	Antitoxin
VEIS_RS20975	4782809..4783108	+	300	WP_011812030.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VEIS_RS20980	4783445..4785748	+	2304	WP_041950241.1	Ig-like domain-containing protein	-
VEIS_RS20985	4785813..4786046	-	234	WP_041950242.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11650.37 Da
• Isoelectric Point: 6.9771

>T21923 WP_011812030.1 NC_008786:4782809-4783108 [Verminephrobacter eiseniae EF01-2]
MLPIFWLETADTDLADITQYIGLRDINAAERMWHRLRNCVLPLSEHPYLYRISERVPGLREIVAHPNYLVLYRVTATRIE
VVNVVHTRREFPQHSNDGP

Nucleotide

• Length: 300 bp

>T21923 NC_008786:4782809-4783108 [Verminephrobacter eiseniae EF01-2]
ATGCTGCCGATCTTCTGGCTAGAGACAGCCGACACCGATCTGGCCGACATCACACAATACATCGGCCTGCGCGACATCAA
TGCAGCAGAGCGCATGTGGCACCGCCTGCGCAACTGCGTCCTGCCGCTGTCAGAGCACCCATACCTATACCGCATCAGCG
AGCGTGTTCCCGGTCTGCGCGAAATCGTCGCGCATCCCAACTACCTCGTGTTGTACCGGGTCACAGCGACCCGCATCGAA
GTCGTGAACGTGGTGCATACCCGTCGTGAATTCCCCCAGCACTCCAATGACGGCCCCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7049.91 Da
• Isoelectric Point: 6.4573

>AT21923 WP_011812029.1 NC_008786:4782621-4782809 [Verminephrobacter eiseniae EF01-2]
MSTDLSPIVSEFETSDQQASYTEWLRAKVAASLADPRPAIPHDEVERRMAQRLAQLRKHQVS

Nucleotide

• Length: 189 bp

>AT21923 NC_008786:4782621-4782809 [Verminephrobacter eiseniae EF01-2]
ATGAGCACCGATCTTTCCCCGATCGTCTCGGAGTTCGAAACCTCCGACCAGCAAGCCAGCTACACCGAATGGCTACGCGC
CAAGGTCGCGGCCAGTCTTGCCGACCCGCGCCCGGCTATTCCTCATGATGAGGTAGAGCGGCGTATGGCTCAACGACTGG
CTCAGCTACGCAAGCACCAAGTGTCCTGA

Structures

Toxin

• AlphaFold DB: A1WQY7