Detailed information of TA system TA219227

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 448116..448769
• Replicon: chromosome
• Accession: NZ_CP084721
• Organism: Acinetobacter baumannii strain HKU7

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LHJ63_RS02185
• Protein ID: WP_000607077.1
• Coordinates: 448380..448769 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: LHJ63_RS02180
• Protein ID: WP_001288210.1
• Coordinates: 448116..448373 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHJ63_RS02160 (LHJ63_02160)	443632..444639	+	1008	WP_226511731.1	DNA-directed RNA polymerase subunit alpha	-
LHJ63_RS02165 (LHJ63_02165)	444658..445035	+	378	WP_001216380.1	50S ribosomal protein L17	-
LHJ63_RS02170 (LHJ63_02170)	445217..446707	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
LHJ63_RS02175 (LHJ63_02175)	446756..447928	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
LHJ63_RS02180 (LHJ63_02180)	448116..448373	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
LHJ63_RS02185 (LHJ63_02185)	448380..448769	+	390	WP_000607077.1	membrane protein	Toxin
LHJ63_RS02190 (LHJ63_02190)	449539..450624	+	1086	WP_000049106.1	hypothetical protein	-
LHJ63_RS02195 (LHJ63_02195)	450702..451268	+	567	WP_000651538.1	rhombosortase	-
LHJ63_RS02200 (LHJ63_02200)	451456..453651	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T219227 WP_000607077.1 NZ_CP084721:448380-448769 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T219227 NZ_CP116215:227980-228510 [Klebsiella michiganensis]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTTACTGACCATCTGAAACGCCAGCACAACAGTAAGATTTTGCGTGGCTATCTGCTCGTGACGAGAGAGG
ATAAACCACGTGTTATGGGGTACTACACGCTGTCTGGCAGCTGCTTTGAGAAAACACTTCTACCCAGCAAAACGCAACAA
AAGCGCGTCCCCTACAAAAATGTGCCGAGCGTGACTTTAGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCTATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AAGCGCTGAACGACAACGCCAAAAAATTCTACCTTCGCCTGGGTTTTATACAGTTAAAAGAAGAAAACAGTAATTCGCTC
TTCTACCCGACAAAATCTGTTGAAGAATTGTTCGAAGTAAAAGATGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT219227 WP_001288210.1 NZ_CP084721:448116-448373 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT219227 NZ_CP116215:227707-227976 [Klebsiella michiganensis]
ATGTCAGCACTGAAAAAGCAGCGCATTGACCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCAATTTCGCAGTTCATGGTCAGTACCGCCTCAGAACGCGCTGCAGAAGTTATTGACCAGCACCGTCGTC
TGCTCCTCAATGAGGAGTCCTGGAACCTGGTTATGGATGCAATCACTAATCCGCCAGTACCGAATGACCGGCTGAAACGC
GCCGCTAACCGTCTCCGGGAACTGGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7