Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 878161..878942 Replicon chromosome
Accession NZ_CP084719
Organism Staphylococcus chromogenes strain 76ME

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag LGV34_RS04300 Protein ID WP_157946143.1
Coordinates 878778..878942 (+) Length 55 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag LGV34_RS04295 Protein ID WP_037577237.1
Coordinates 878161..878760 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGV34_RS04275 (LGV34_04275) 874347..875069 + 723 WP_037577247.1 amino acid ABC transporter ATP-binding protein -
LGV34_RS04280 (LGV34_04280) 875355..876488 + 1134 WP_037577244.1 tRNA epoxyqueuosine(34) reductase QueG -
LGV34_RS04285 (LGV34_04285) 876485..876955 + 471 WP_037577242.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LGV34_RS04290 (LGV34_04290) 876973..878142 + 1170 WP_268217064.1 N-acetylglucosamine-6-phosphate deacetylase -
LGV34_RS04295 (LGV34_04295) 878161..878760 + 600 WP_037577237.1 glucosamine-6-phosphate isomerase Antitoxin
LGV34_RS04300 (LGV34_04300) 878778..878942 + 165 WP_157946143.1 SAS053 family protein Toxin
LGV34_RS04305 (LGV34_04305) 879042..879452 + 411 WP_037577235.1 hypothetical protein -
LGV34_RS04310 (LGV34_04310) 879597..880982 + 1386 WP_268217065.1 class II fumarate hydratase -
LGV34_RS04315 (LGV34_04315) 881004..882530 + 1527 WP_268217066.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(135-197)


Sequences

Toxin        


Download         Length: 55 a.a.        Molecular weight: 6336.71 Da        Isoelectric Point: 3.9165

>T219226 WP_157946143.1 NZ_CP084719:878778-878942 [Staphylococcus chromogenes]
MTEEKHIEHENEMVDDFDDLVSLGKEMEQISETNDEEKVNQTHDASIRSDKTEE

Download         Length: 165 bp

>T219226 NZ_CP116215:63806-64093 [Klebsiella michiganensis]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22353.29 Da        Isoelectric Point: 6.1496

>AT219226 WP_037577237.1 NZ_CP084719:878161-878760 [Staphylococcus chromogenes]
MAMNFKVFKDKDTAAIYAADIIRKQFNNNPTTIAGFHLSGEEAPVLDYLKRNVDNHAVDFSQIHVLDYDKQTSYFKALGV
PEKQIHEIPEDDDVEKFIEHKAKTKDNKGKLTLQVVSINQNGEFGVPVNNGLKPAREIFVIVTGHDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPADVREYFTSLYA

Download         Length: 600 bp

>AT219226 NZ_CP116215:63567-63806 [Klebsiella michiganensis]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References