219222

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5731322..5731892 Replicon chromosome
Accession NZ_CP084713
Organism Mycolicibacterium phocaicum strain RL-HY01

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LHJ73_RS27800 Protein ID WP_226520050.1
Coordinates 5731322..5731669 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7I7ZUA3
Locus tag LHJ73_RS27805 Protein ID WP_064861194.1
Coordinates 5731656..5731892 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHJ73_RS27795 (LHJ73_27795) 5728114..5731311 + 3198 WP_138251098.1 arabinosyltransferase domain-containing protein -
LHJ73_RS27800 (LHJ73_27800) 5731322..5731669 - 348 WP_226520050.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LHJ73_RS27805 (LHJ73_27805) 5731656..5731892 - 237 WP_064861194.1 hypothetical protein Antitoxin
LHJ73_RS27810 (LHJ73_27810) 5732070..5735318 + 3249 WP_226520051.1 arabinosyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12045.14 Da        Isoelectric Point: 10.6577

>T219222 WP_226520050.1 NZ_CP084713:c5731669-5731322 [Mycolicibacterium phocaicum]
MTSAEPHRGDLWLVALGAGRAGEPTKHRPAVVLSVDDLLTGEPTELVVVVPVSSSRIATPLRPTIRPGEGVEVDSVAVCR
AVRGIARGRLVRRLGVLAAPTMGQIEKSLALILGI

Download         Length: 348 bp

>T219222 NZ_CP116214:2163015-2163118 [Klebsiella michiganensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8538.25 Da        Isoelectric Point: 4.0717

>AT219222 WP_064861194.1 NZ_CP084713:c5731892-5731656 [Mycolicibacterium phocaicum]
MATPTTTIRVPVATRDRLNARARDHGISVVALLDEWANRAEREDAFAAERAATVAEATNEAVIEEDQDWGQTDTDDLG

Download         Length: 237 bp

>AT219222 NZ_CP116214:c2163125-2162957 [Klebsiella michiganensis]
AACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGCGACAAAAGTG
GACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7ZUA3

References