Detailed information of TA system TA219220

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 3517980..3518496
• Replicon: chromosome
• Accession: NZ_CP084713
• Organism: Mycolicibacterium phocaicum strain RL-HY01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LHJ73_RS16925
• Protein ID: WP_226518727.1
• Coordinates: 3518242..3518496 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LHJ73_RS16920
• Protein ID: WP_226518726.1
• Coordinates: 3517980..3518231 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHJ73_RS16905 (LHJ73_16905)	3513429..3515687	+	2259	WP_226518723.1	malto-oligosyltrehalose synthase	-
LHJ73_RS16910 (LHJ73_16910)	3515680..3517395	+	1716	WP_226518724.1	malto-oligosyltrehalose trehalohydrolase	-
LHJ73_RS16915 (LHJ73_16915)	3517479..3517916	+	438	WP_226518725.1	hypothetical protein	-
LHJ73_RS16920 (LHJ73_16920)	3517980..3518231	+	252	WP_226518726.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LHJ73_RS16925 (LHJ73_16925)	3518242..3518496	+	255	WP_226518727.1	Txe/YoeB family addiction module toxin	Toxin
LHJ73_RS16930 (LHJ73_16930)	3518658..3520061	-	1404	WP_138248127.1	IS1380 family transposase	-
LHJ73_RS16935 (LHJ73_16935)	3520181..3521464	-	1284	WP_226518728.1	threonine ammonia-lyase IlvA	-
LHJ73_RS16940 (LHJ73_16940)	3521564..3522244	+	681	WP_226522195.1	hypothetical protein	-
LHJ73_RS16945 (LHJ73_16945)	3522249..3523094	-	846	WP_226518729.1	patatin-like phospholipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3518658..3520061	1403

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-67)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10118.51 Da
• Isoelectric Point: 10.4214

>T219220 WP_226518727.1 NZ_CP084713:3518242-3518496 [Mycolicibacterium phocaicum]
VNVVFAPQAWEDYQYWQSTDRTLVKRINRLINEIRRSPYKGIGKPEPLKYGLAGAWSRRITDQHRLVYRVNNNDLQILQA
RYHY

Nucleotide

• Length: 255 bp

>T219220 NZ_CP116214:c1327869-1327495 [Klebsiella michiganensis]
ATGCAAAAACAATCCCTGTCCCCTCATAGGGCGGCCTCGTCACGTCTGTCATCAGTCGAAATCTGGCGAAAATTATTGAA
GTATCTGCTGGAGCAACACTACGGCCTTACCCTCAACGACACACCGTTTGGCAACGACAGTGTGATCCAGAAGCACATTG
ATGCGGGAATCTCACTGTGTTACGCGGTGAATTTTATCGTGGAAAAGTACGACCTGGTGCGTACTGACCGTCACGGCTTC
AGCGTGAAAGAGCAGTCTCCGTTTATCGGCAGCATTGATATGCTCCGCGCCAGGAAGGCTACCGGGCTGATGACACGCAA
GGGATATAAAACCGTTACTGACATCTCAGGTGGCAGATCCAGCGGAGGGAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9139.20 Da
• Isoelectric Point: 4.4354

>AT219220 WP_226518726.1 NZ_CP084713:3517980-3518231 [Mycolicibacterium phocaicum]
MAITASEARKRLFPLIEQVNNDRAPVEITSKNGRAVLMAADEWEAWQETAYLFRSPQNARRLLDAAAALDGGHGVSVELD
ADE

Nucleotide

• Length: 252 bp

>AT219220 NZ_CP116214:c1328278-1327919 [Klebsiella michiganensis]
ATGCAGAAAGCAACCCGTGTAATCAACCATAACATCGCGGAACCCTGGTGGGGCCTCAGACGCAACATCACACCGTGTTT
TGGTGCACGACTGGTACATGAGGGTAACCACCTGCATTACCTTGCTGACCGCGCCAGCATTGCCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGGTACTGATGAAACAGATGGAGCTCATGCTGACCAGTAGCGAACTCACG
CCCCACATTCAGCGCTGCATTACGCTCCACGCAAAAGGGCTGATATGTGAGGCCGATACGCTCGGCTCCTGTGGCTATTT
GTACATCGTAATTTATCCGGCGTCTGCAACAACCGCATAA