Detailed information of TA system TA021922

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 4579026..4580065
• Replicon: chromosome
• Accession: NC_008786
• Organism: Verminephrobacter eiseniae EF01-2

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: VEIS_RS20160
• Protein ID: WP_011811855.1
• Coordinates: 4579490..4580065 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A1WQG0
• Locus tag: VEIS_RS20155
• Protein ID: WP_011811854.1
• Coordinates: 4579026..4579493 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VEIS_RS20130	4574174..4575073	-	900	WP_011811849.1	serine/threonine-protein phosphatase	-
VEIS_RS20135	4575070..4576092	-	1023	WP_011811850.1	serine/threonine protein kinase	-
VEIS_RS20140	4576169..4577086	+	918	WP_011811851.1	YicC family protein	-
VEIS_RS20145	4577297..4578556	+	1260	WP_011811852.1	site-specific integrase	-
VEIS_RS20150	4578609..4578920	+	312	WP_041950223.1	DNA-binding protein	-
VEIS_RS20155	4579026..4579493	+	468	WP_011811854.1	helix-turn-helix domain-containing protein	Antitoxin
VEIS_RS20160	4579490..4580065	+	576	WP_011811855.1	PIN domain-containing protein	Toxin
VEIS_RS20165	4580135..4580539	-	405	WP_011811856.1	hypothetical protein	-
VEIS_RS20170	4580576..4581583	-	1008	WP_049773979.1	integrase domain-containing protein	-
VEIS_RS20175	4582360..4582887	+	528	WP_011811858.1	hypothetical protein	-
VEIS_RS20180	4582999..4584054	+	1056	WP_011811859.1	Fic family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-114)

Antitoxin

• SinI-like, DNA-binding domain (84-130)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21375.54 Da
• Isoelectric Point: 5.2492

>T21922 WP_011811855.1 NC_008786:4579490-4580065 [Verminephrobacter eiseniae EF01-2]
MRQSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSTQIHEEWKRNLLINRPDLRPDQVDRTSALMDQAIPDGLVSDY
EALIAGLRLPDPDDCHVLAAAIRCGASVIVTFNEKDFPQAALAPFGIEAQHPDLFIDNLFDLDAAAVVSAAQKQRAQLKS
PPLDVDRYLDALLRQGLVQTVKALSTYRTIL

Nucleotide

• Length: 576 bp

>T21922 NC_008786:4579490-4580065 [Verminephrobacter eiseniae EF01-2]
ATGAGGCAGTCGCCATTCACGGCCGTCTATGACGCATGCGTGTTGTACCCGGCGCCGTTACGGGACTTTCTCATGTGGCT
GGGTCTTTCCGGCCGCTTCCGGGCACGTTGGAGTACGCAGATCCACGAGGAATGGAAACGCAACCTGCTGATCAACCGCC
CGGATCTTCGCCCCGATCAGGTTGACCGCACATCGGCATTGATGGACCAGGCCATCCCGGATGGCTTGGTCTCGGATTAC
GAAGCGCTCATCGCCGGATTGCGCCTGCCAGACCCGGACGACTGCCATGTCCTGGCTGCGGCCATCCGTTGCGGCGCCAG
CGTCATCGTGACCTTCAACGAAAAGGATTTTCCGCAGGCAGCGCTCGCGCCCTTCGGCATCGAGGCGCAGCATCCAGACC
TTTTCATCGACAACCTGTTCGACCTGGATGCGGCAGCAGTGGTATCGGCAGCGCAGAAGCAGCGGGCGCAGTTGAAGAGC
CCGCCACTGGATGTGGATCGCTACCTCGACGCGTTGTTGCGACAAGGTCTGGTCCAGACCGTCAAGGCACTTTCGACCTA
TCGGACCATTCTCTGA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17117.67 Da
• Isoelectric Point: 6.3392

>AT21922 WP_011811854.1 NC_008786:4579026-4579493 [Verminephrobacter eiseniae EF01-2]
MSTAALVNVSLPVEREVQAALEGQRALAAFLATRVETQQIQIFDDKNQAHRVELPTSALRLLVDILAELAEGNAVKVVPV
HAELTTQEAADMLNVSRPHLVKLLEEGALPFHRAGKHRRVRFVDLMQFKARRDQASEDAMAALAKQAQELGMGYE

Nucleotide

• Length: 468 bp

>AT21922 NC_008786:4579026-4579493 [Verminephrobacter eiseniae EF01-2]
ATGTCCACCGCTGCCCTTGTCAACGTGTCGCTGCCCGTCGAGCGTGAGGTGCAGGCCGCCCTGGAAGGACAGCGAGCCTT
GGCCGCCTTCCTGGCCACGCGCGTGGAAACGCAGCAGATCCAGATTTTCGACGACAAGAACCAAGCCCATCGGGTGGAGC
TGCCCACGTCCGCGCTGCGCCTGCTGGTGGACATCCTGGCGGAGCTCGCCGAAGGCAATGCCGTCAAGGTGGTGCCGGTC
CATGCCGAACTCACGACCCAGGAGGCCGCCGACATGCTCAATGTGTCCCGGCCACACTTGGTCAAGCTACTCGAAGAGGG
TGCACTTCCCTTCCACAGGGCCGGCAAGCATCGGCGCGTCCGCTTTGTCGACCTGATGCAGTTCAAGGCCCGGAGAGACC
AAGCCAGCGAAGACGCCATGGCGGCGTTGGCGAAACAGGCTCAGGAACTGGGCATGGGCTACGAATGA

Structures

Antitoxin

• AlphaFold DB: A1WQG0