Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2211275..2211936 Replicon chromosome
Accession NZ_CP084713
Organism Mycolicibacterium phocaicum strain RL-HY01

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A0M3J0
Locus tag LHJ73_RS10555 Protein ID WP_064860475.1
Coordinates 2211275..2211700 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1A0M4A7
Locus tag LHJ73_RS10560 Protein ID WP_064860474.1
Coordinates 2211697..2211936 (-) Length 80 a.a.

Genomic Context

LHJ73_RS10520LHJ73_RS10525LHJ73_RS10530LHJ73_RS10535LHJ73_RS10540LHJ73_RS10545LHJ73_RS10550LHJ73_RS10565LHJ73_RS10570LHJ73_RS10555LHJ73_RS10560
Location: 2206331..2206918 (588 bp)
Type: Others
Protein ID: WP_064860478.1
Location: 2206946..2207827 (882 bp)
Type: Others
Protein ID: WP_226521550.1
Location: 2207837..2209111 (1275 bp)
Type: Others
Protein ID: WP_133428395.1
Location: 2209190..2209816 (627 bp)
Type: Others
Protein ID: WP_135356614.1
Location: 2209897..2210118 (222 bp)
Type: Others
Protein ID: WP_138248766.1
Location: 2210134..2210418 (285 bp)
Type: Others
Protein ID: WP_061001018.1
Location: 2210537..2211013 (477 bp)
Type: Others
Protein ID: WP_064860476.1
Location: 2212045..2213499 (1455 bp)
Type: Others
Protein ID: WP_226521551.1
Location: 2213496..2214095 (600 bp)
Type: Others
Protein ID: WP_226521552.1
Location: 2211275..2211700 (426 bp)
Type: Toxin
Protein ID: WP_064860475.1
Location: 2211697..2211936 (240 bp)
Type: Antitoxin
Protein ID: WP_064860474.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LHJ73_RS10520 (LHJ73_10520)2206331..2206918+588WP_064860478.1hypothetical protein-
LHJ73_RS10525 (LHJ73_10525)2206946..2207827+882WP_226521550.1class A beta-lactamase-
LHJ73_RS10530 (LHJ73_10530)2207837..2209111+1275WP_133428395.1hypothetical protein-
LHJ73_RS10535 (LHJ73_10535)2209190..2209816+627WP_135356614.1dihydrofolate reductase family protein-
LHJ73_RS10540 (LHJ73_10540)2209897..2210118+222WP_138248766.1hypothetical protein-
LHJ73_RS10545 (LHJ73_10545)2210134..2210418+285WP_061001018.1hypothetical protein-
LHJ73_RS10550 (LHJ73_10550)2210537..2211013+477WP_064860476.1DIP1984 family protein-
LHJ73_RS10555 (LHJ73_10555)2211275..2211700-426WP_064860475.1type II toxin-antitoxin system VapC family toxinToxin
LHJ73_RS10560 (LHJ73_10560)2211697..2211936-240WP_064860474.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
LHJ73_RS10565 (LHJ73_10565)2212045..2213499+1455WP_226521551.1DUF3375 domain-containing protein-
LHJ73_RS10570 (LHJ73_10570)2213496..2214095+600WP_226521552.1DUF4194 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-126)

Antitoxin

SpoVT-AbrB domain

(4-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14605.41 Da        Isoelectric Point: 5.8844

>T219216 WP_064860475.1 NZ_CP084713:c2211700-2211275 [Mycolicibacterium phocaicum]
MTSQQVTAIDTSVAVPLLVTSHPQHVAISQWAMGRRLGLSGHALAETYSVLTRLPGDARVDPADAVTLIDENFPEPLQLS
ADAAGGAHREFARRGVAGGATYDGLVALAAHEHGAVLVTRDARAKATYDAIGVNTEVLAGA

Download         Length: 426 bp

>T219216 NZ_CP116214:40526-40867 [Klebsiella michiganensis]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8358.65 Da        Isoelectric Point: 10.2024

>AT219216 WP_064860474.1 NZ_CP084713:c2211936-2211697 [Mycolicibacterium phocaicum]
MEAVIDSGGRILVPKQLRDALGLTPGSTVDISAYGPGLQIVPGGRSARLVRNKDGRLVANAHTVVTDEMMFALIDSGRR

Download         Length: 240 bp

>AT219216 NZ_CP116214:40877-41176 [Klebsiella michiganensis]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AGCCCACCATTGCTAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1A0M3J0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1A0M4A7

References