219216

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2211275..2211936 Replicon chromosome
Accession NZ_CP084713
Organism Mycolicibacterium phocaicum strain RL-HY01

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A0M3J0
Locus tag LHJ73_RS10555 Protein ID WP_064860475.1
Coordinates 2211275..2211700 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1A0M4A7
Locus tag LHJ73_RS10560 Protein ID WP_064860474.1
Coordinates 2211697..2211936 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHJ73_RS10520 (LHJ73_10520) 2206331..2206918 + 588 WP_064860478.1 hypothetical protein -
LHJ73_RS10525 (LHJ73_10525) 2206946..2207827 + 882 WP_226521550.1 class A beta-lactamase -
LHJ73_RS10530 (LHJ73_10530) 2207837..2209111 + 1275 WP_133428395.1 hypothetical protein -
LHJ73_RS10535 (LHJ73_10535) 2209190..2209816 + 627 WP_135356614.1 dihydrofolate reductase family protein -
LHJ73_RS10540 (LHJ73_10540) 2209897..2210118 + 222 WP_138248766.1 hypothetical protein -
LHJ73_RS10545 (LHJ73_10545) 2210134..2210418 + 285 WP_061001018.1 hypothetical protein -
LHJ73_RS10550 (LHJ73_10550) 2210537..2211013 + 477 WP_064860476.1 DIP1984 family protein -
LHJ73_RS10555 (LHJ73_10555) 2211275..2211700 - 426 WP_064860475.1 type II toxin-antitoxin system VapC family toxin Toxin
LHJ73_RS10560 (LHJ73_10560) 2211697..2211936 - 240 WP_064860474.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LHJ73_RS10565 (LHJ73_10565) 2212045..2213499 + 1455 WP_226521551.1 DUF3375 domain-containing protein -
LHJ73_RS10570 (LHJ73_10570) 2213496..2214095 + 600 WP_226521552.1 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-126)

Antitoxin

SpoVT-AbrB domain

(4-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14605.41 Da        Isoelectric Point: 5.8844

>T219216 WP_064860475.1 NZ_CP084713:c2211700-2211275 [Mycolicibacterium phocaicum]
MTSQQVTAIDTSVAVPLLVTSHPQHVAISQWAMGRRLGLSGHALAETYSVLTRLPGDARVDPADAVTLIDENFPEPLQLS
ADAAGGAHREFARRGVAGGATYDGLVALAAHEHGAVLVTRDARAKATYDAIGVNTEVLAGA

Download         Length: 426 bp

>T219216 NZ_CP116214:40526-40867 [Klebsiella michiganensis]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8358.65 Da        Isoelectric Point: 10.2024

>AT219216 WP_064860474.1 NZ_CP084713:c2211936-2211697 [Mycolicibacterium phocaicum]
MEAVIDSGGRILVPKQLRDALGLTPGSTVDISAYGPGLQIVPGGRSARLVRNKDGRLVANAHTVVTDEMMFALIDSGRR

Download         Length: 240 bp

>AT219216 NZ_CP116214:40877-41176 [Klebsiella michiganensis]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AGCCCACCATTGCTAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A0M3J0

Antitoxin

Source ID Structure
AlphaFold DB A0A1A0M4A7

References