Detailed information of TA system TA219215

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 1438605..1439182
• Replicon: chromosome
• Accession: NZ_CP084713
• Organism: Mycolicibacterium phocaicum strain RL-HY01

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: LHJ73_RS06960
• Protein ID: WP_226521146.1
• Coordinates: 1438799..1439182 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: LHJ73_RS06955
• Protein ID: WP_071288080.1
• Coordinates: 1438605..1438802 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHJ73_RS06930 (LHJ73_06930)	1433780..1434079	-	300	WP_226521141.1	GreA/GreB family elongation factor	-
LHJ73_RS06935 (LHJ73_06935)	1434324..1434851	+	528	WP_226521142.1	SWIM zinc finger family protein	-
LHJ73_RS06940 (LHJ73_06940)	1434860..1435987	+	1128	WP_226521143.1	hypothetical protein	-
LHJ73_RS06945 (LHJ73_06945)	1436157..1436372	-	216	WP_226521144.1	antitoxin	-
LHJ73_RS06950 (LHJ73_06950)	1436488..1438467	-	1980	WP_226521145.1	oligopeptide transporter, OPT family	-
LHJ73_RS06955 (LHJ73_06955)	1438605..1438802	+	198	WP_071288080.1	antitoxin Phd	Antitoxin
LHJ73_RS06960 (LHJ73_06960)	1438799..1439182	+	384	WP_226521146.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
LHJ73_RS06965 (LHJ73_06965)	1439179..1440807	-	1629	WP_226521147.1	peptide chain release factor 3	-
LHJ73_RS06970 (LHJ73_06970)	1440876..1442687	-	1812	WP_226521148.1	sulfatase-like hydrolase/transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1365252..1439182	73930

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (23-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 13780.40 Da
• Isoelectric Point: 4.1309

>T219215 WP_226521146.1 NZ_CP084713:1438799-1439182 [Mycolicibacterium phocaicum]
VIEYLDREDVLTAGSIAFGSELKVRDYGLLDAAVARPQATVFGVDAYPDVWDKAAALLQSLARNHALVDGNKRTAWASAW
TFLHINGDELAPDFDVDRAEELMNTVATQELELSEIASALRGFAVAS

Nucleotide

• Length: 384 bp

>T219215 NZ_CP116204:2475356-2476093 [Bacillus paranthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAATACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACATCAATCATTCAAAATGTCAATCCAGTAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGTATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7248.29 Da
• Isoelectric Point: 8.8756

>AT219215 WP_071288080.1 NZ_CP084713:1438605-1438802 [Mycolicibacterium phocaicum]
MPSLNIDFDDAEMEQIRAAAKADDLSLKKFAHAAVVERASMHKRRVAEAARVVAERSAELNRRLA

Nucleotide

• Length: 198 bp

>AT219215 NZ_CP116204:2476206-2476331 [Bacillus paranthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA