Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PhRel-ATphRel/- |
| Location | 1277241..1278162 | Replicon | chromosome |
| Accession | NZ_CP084713 | ||
| Organism | Mycolicibacterium phocaicum strain RL-HY01 | ||
Toxin (Protein)
| Gene name | phRel | Uniprot ID | - |
| Locus tag | LHJ73_RS06200 | Protein ID | WP_226521039.1 |
| Coordinates | 1277458..1278162 (-) | Length | 235 a.a. |
Antitoxin (Protein)
| Gene name | ATphRel | Uniprot ID | - |
| Locus tag | LHJ73_RS06195 | Protein ID | WP_226521038.1 |
| Coordinates | 1277241..1277456 (-) | Length | 72 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LHJ73_RS06170 (LHJ73_06170) | 1272530..1273426 | + | 897 | WP_226521034.1 | LLM class flavin-dependent oxidoreductase | - |
| LHJ73_RS06175 (LHJ73_06175) | 1273423..1274670 | + | 1248 | WP_226521035.1 | amidohydrolase | - |
| LHJ73_RS06180 (LHJ73_06180) | 1274610..1275101 | - | 492 | WP_226521036.1 | hypothetical protein | - |
| LHJ73_RS06185 (LHJ73_06185) | 1275281..1275928 | + | 648 | WP_226521037.1 | DUF1942 domain-containing protein | - |
| LHJ73_RS06190 (LHJ73_06190) | 1276012..1276909 | + | 898 | Protein_1213 | IS5 family transposase | - |
| LHJ73_RS06195 (LHJ73_06195) | 1277241..1277456 | - | 216 | WP_226521038.1 | hypothetical protein | Antitoxin |
| LHJ73_RS06200 (LHJ73_06200) | 1277458..1278162 | - | 705 | WP_226521039.1 | hypothetical protein | Toxin |
| LHJ73_RS06210 (LHJ73_06210) | 1278876..1279466 | + | 591 | WP_052568745.1 | hypothetical protein | - |
| LHJ73_RS06215 (LHJ73_06215) | 1279587..1281038 | + | 1452 | WP_226519117.1 | DDE-type integrase/transposase/recombinase | - |
| LHJ73_RS06220 (LHJ73_06220) | 1281077..1281850 | + | 774 | WP_226522041.1 | AAA family ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 235 a.a. Molecular weight: 25959.05 Da Isoelectric Point: 6.2423
>T219213 WP_226521039.1 NZ_CP084713:c1278162-1277458 [Mycolicibacterium phocaicum]
VAAILTNTQWSNKPTGQFAVTARSKTVDTLIQKLARSSSKLDRVQDIAGVRIDADMSLTQQTLLAHEIADYFGRERATVK
DLRDAPHSGYRAVHIWLIVPAGRAEVQIRTLHQSEWANTYEGIADLVGRGIRYNEPSDNERTQRIVQAMHELSKRIARDE
KNADQIANVVDNLVQAVFDQPGGSSAPDPGLIDQALEALSSLGDRAVDFQARLKQTSEHLRSLRRILDGEEVEG
VAAILTNTQWSNKPTGQFAVTARSKTVDTLIQKLARSSSKLDRVQDIAGVRIDADMSLTQQTLLAHEIADYFGRERATVK
DLRDAPHSGYRAVHIWLIVPAGRAEVQIRTLHQSEWANTYEGIADLVGRGIRYNEPSDNERTQRIVQAMHELSKRIARDE
KNADQIANVVDNLVQAVFDQPGGSSAPDPGLIDQALEALSSLGDRAVDFQARLKQTSEHLRSLRRILDGEEVEG
Download Length: 705 bp
>T219213 NZ_CP116200:40887-41039 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 72 a.a. Molecular weight: 8105.06 Da Isoelectric Point: 5.6746
>AT219213 WP_226521038.1 NZ_CP084713:c1277456-1277241 [Mycolicibacterium phocaicum]
VPGFVIEFNRHTGDRRVTEFATAREAMERRLELEAERTNQGVEIVALISDSLNTLRQTHSRYFTGNELAAI
VPGFVIEFNRHTGDRRVTEFATAREAMERRLELEAERTNQGVEIVALISDSLNTLRQTHSRYFTGNELAAI
Download Length: 216 bp
>AT219213 NZ_CP116200:c40835-40775 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|