219212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 703361..704022 Replicon chromosome
Accession NZ_CP084713
Organism Mycolicibacterium phocaicum strain RL-HY01

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag LHJ73_RS03315 Protein ID WP_226520666.1
Coordinates 703585..704022 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag LHJ73_RS03310 Protein ID WP_226520665.1
Coordinates 703361..703582 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHJ73_RS03295 (LHJ73_03295) 698974..699708 + 735 WP_226520662.1 enoyl-CoA hydratase -
LHJ73_RS03300 (LHJ73_03300) 699708..700823 + 1116 WP_226520663.1 MBL fold metallo-hydrolase -
LHJ73_RS03305 (LHJ73_03305) 700897..703311 + 2415 WP_226520664.1 HAD-IC family P-type ATPase -
LHJ73_RS03310 (LHJ73_03310) 703361..703582 + 222 WP_226520665.1 antitoxin Antitoxin
LHJ73_RS03315 (LHJ73_03315) 703585..704022 + 438 WP_226520666.1 SRPBCC family protein Toxin
LHJ73_RS03320 (LHJ73_03320) 704168..704938 + 771 WP_226520667.1 VOC family protein -
LHJ73_RS03325 (LHJ73_03325) 705046..705306 + 261 WP_212813138.1 hypothetical protein -
LHJ73_RS03330 (LHJ73_03330) 705314..706993 - 1680 WP_226520668.1 NAD-binding protein -
LHJ73_RS03335 (LHJ73_03335) 706999..707439 - 441 WP_226520669.1 cupin domain-containing protein -
LHJ73_RS03340 (LHJ73_03340) 707502..707912 + 411 WP_226520670.1 hypothetical protein -
LHJ73_RS03345 (LHJ73_03345) 707909..708499 + 591 WP_226520671.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15566.03 Da        Isoelectric Point: 9.5944

>T219212 WP_226520666.1 NZ_CP084713:703585-704022 [Mycolicibacterium phocaicum]
MAKLSSSIEVPLSPEKAWEAASDLSRYDDWLSIHRMWRSPLPETLGKGTQISSVVEVKGMLNRVDWTIVHYNPPGSLTLN
GVGKGGVRVKLMAKITPAGDGSNVAFDIHLGGPALFGPIGMVVAAALRSDIHQSLEKFKALFASV

Download         Length: 438 bp

>T219212 NZ_CP116199:52784-53182 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7513.28 Da        Isoelectric Point: 4.2092

>AT219212 WP_226520665.1 NZ_CP084713:703361-703582 [Mycolicibacterium phocaicum]
MGFLDKVKDLAAQNADKVEAAIEKVGDIVDEKTEGKFKGAVDSAQEAAKKAVAGDQSAEAPAAPPAEGTQEQQ

Download         Length: 222 bp

>AT219212 NZ_CP116199:52557-52784 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References