219211

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2131038..2131627 Replicon chromosome
Accession NZ_CP084712
Organism Sphingopyxis sp. USTB-05

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KEC45_RS09690 Protein ID WP_062180040.1
Coordinates 2131038..2131406 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KEC45_RS09695 Protein ID WP_062180036.1
Coordinates 2131403..2131627 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC45_RS09665 (KEC45_09675) 2126869..2127531 - 663 WP_062180054.1 HAD family phosphatase -
KEC45_RS09670 (KEC45_09680) 2127591..2127779 + 189 WP_062180051.1 hypothetical protein -
KEC45_RS09675 (KEC45_09685) 2127791..2128204 - 414 WP_062180048.1 hypothetical protein -
KEC45_RS09680 (KEC45_09690) 2128217..2129164 - 948 WP_252171987.1 hypothetical protein -
KEC45_RS09685 (KEC45_09695) 2129198..2131021 - 1824 WP_062180043.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
KEC45_RS09690 (KEC45_09700) 2131038..2131406 - 369 WP_062180040.1 PIN domain-containing protein Toxin
KEC45_RS09695 (KEC45_09705) 2131403..2131627 - 225 WP_062180036.1 ribbon-helix-helix domain-containing protein Antitoxin
KEC45_RS09700 (KEC45_09710) 2131658..2132122 - 465 WP_062180033.1 GNAT family N-acetyltransferase -
KEC45_RS09705 (KEC45_09715) 2132119..2132433 - 315 WP_062180030.1 hypothetical protein -
KEC45_RS09710 (KEC45_09720) 2132430..2132966 - 537 WP_062180027.1 GNAT family N-acetyltransferase -
KEC45_RS09715 (KEC45_09725) 2132971..2134323 - 1353 WP_238586626.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
KEC45_RS09720 (KEC45_09730) 2134383..2135045 + 663 WP_062180021.1 HAD-IA family hydrolase -
KEC45_RS09725 (KEC45_09735) 2135137..2136150 - 1014 WP_083435756.1 nucleotidyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-105)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-38)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13133.21 Da        Isoelectric Point: 9.1636

>T219211 WP_062180040.1 NZ_CP084712:c2131406-2131038 [Sphingopyxis sp. USTB-05]
MIDAQFDSDILIDALNGIEAARAEIRRAGRKSVSRVSWTEVMSAADPTSVKAVEAFLGCFQVEEIGDAVARRAAALRAER
KGLTLADAFVLATAQISGRILVTRNIKVFPASMPGIRVPYTL

Download         Length: 369 bp

>T219211 NZ_CP116199:c43828-43679 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8352.40 Da        Isoelectric Point: 5.0773

>AT219211 WP_062180036.1 NZ_CP084712:c2131627-2131403 [Sphingopyxis sp. USTB-05]
MRFLADIPDDDIQWLDALAAELGVSRAELVRRAVAAYRADVSGDAIDNAFGIFRTRDDIGDGLKYQRRLRGKRE

Download         Length: 225 bp

>AT219211 NZ_CP116199:43872-43933 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References