Detailed information of TA system TA021921

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 4562688..4563364
• Replicon: chromosome
• Accession: NC_008786
• Organism: Verminephrobacter eiseniae EF01-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: VEIS_RS20080
• Protein ID: WP_011811839.1
• Coordinates: 4562960..4563364 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: VEIS_RS20075
• Protein ID: WP_041951093.1
• Coordinates: 4562688..4562963 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VEIS_RS29175	4559168..4559362	+	195	WP_157048609.1	hypothetical protein	-
VEIS_RS20070	4560067..4562337	+	2271	WP_011811837.1	membrane protein	-
VEIS_RS29180	4562455..4562706	+	252	WP_157048610.1	hypothetical protein	-
VEIS_RS20075	4562688..4562963	+	276	WP_041951093.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
VEIS_RS20080	4562960..4563364	+	405	WP_011811839.1	type II toxin-antitoxin system VapC family toxin	Toxin
VEIS_RS20085	4563582..4564841	-	1260	WP_041951094.1	Zn-dependent hydrolase	-
VEIS_RS20090	4564906..4566357	-	1452	WP_011811841.1	dihydropyrimidinase	-
VEIS_RS20095	4566371..4567852	-	1482	WP_041951095.1	NCS1 family nucleobase:cation symporter-1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• SpoVT-AbrB domain (17-55)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14452.73 Da
• Isoelectric Point: 6.9527

>T21921 WP_011811839.1 NC_008786:4562960-4563364 [Verminephrobacter eiseniae EF01-2]
MSGYLLDTNIISDVIRNPNGPAARRIEQAGPKQIFTSIIVAAELRYGCAKKGSPQLLARVEGLLETVPVLPLDIPADAGY
GGIRAELEAAGQSIGMNDLLIAAHACALGLTLVTDNTREFSRIRKLKVENWLER

Nucleotide

• Length: 405 bp

>T21921 NC_008786:4562960-4563364 [Verminephrobacter eiseniae EF01-2]
TTGAGCGGATATCTGCTGGACACGAACATCATCAGCGATGTGATCCGCAACCCGAACGGGCCTGCGGCACGTCGCATCGA
GCAAGCCGGGCCGAAGCAGATTTTCACCAGCATCATCGTCGCAGCCGAACTGCGCTATGGCTGCGCAAAGAAGGGTTCGC
CCCAGCTGCTCGCCAGGGTGGAAGGCTTGCTCGAAACGGTCCCGGTGCTGCCGCTGGATATTCCGGCTGACGCCGGATAT
GGCGGCATTCGCGCTGAGTTGGAGGCGGCGGGACAGTCCATCGGCATGAACGATTTGCTGATCGCCGCGCACGCCTGTGC
GCTCGGCCTCACGCTGGTGACGGACAACACGCGCGAGTTCAGCCGCATCCGCAAGCTCAAGGTAGAGAACTGGCTGGAGA
GATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10346.06 Da
• Isoelectric Point: 5.8720

>AT21921 WP_041951093.1 NC_008786:4562688-4562963 [Verminephrobacter eiseniae EF01-2]
MPAPLLTPSRPKEAKLFRNNRSQAVRIPVEFELPGDRVMIHREGSKLIVEPVTRPTNIVELLAEWRKEAPLGPEDQLLAI
PDMPARPEDIF

Nucleotide

• Length: 276 bp

>AT21921 NC_008786:4562688-4562963 [Verminephrobacter eiseniae EF01-2]
ATGCCTGCCCCCCTGTTGACGCCATCCAGGCCCAAAGAGGCCAAGCTGTTTCGCAACAACCGCAGCCAGGCGGTGCGGAT
TCCTGTGGAGTTCGAGTTGCCCGGGGATCGTGTGATGATCCACCGCGAAGGCAGCAAACTCATCGTCGAGCCAGTGACCC
GGCCAACGAACATCGTCGAACTACTGGCCGAGTGGAGGAAGGAAGCACCGCTTGGGCCAGAAGATCAGTTGTTGGCCATT
CCTGACATGCCCGCCCGGCCGGAGGACATATTTTGA