Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2028604..2029258 Replicon chromosome
Accession NZ_CP084705
Organism Klebsiella pneumoniae strain KP1064WHY

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag K8U55_RS09925 Protein ID WP_004144731.1
Coordinates 2028851..2029258 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K8U55_RS09920 Protein ID WP_002916312.1
Coordinates 2028604..2028870 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8U55_RS09895 (K8U55_09890) 2023760..2025193 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K8U55_RS09900 (K8U55_09895) 2025312..2026040 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K8U55_RS09905 (K8U55_09900) 2026090..2026401 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
K8U55_RS09910 (K8U55_09905) 2026565..2027224 + 660 WP_002916317.1 hemolysin III family protein -
K8U55_RS09915 (K8U55_09910) 2027375..2028358 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K8U55_RS09920 (K8U55_09915) 2028604..2028870 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K8U55_RS09925 (K8U55_09920) 2028851..2029258 + 408 WP_004144731.1 protein YgfX Toxin
K8U55_RS09930 (K8U55_09925) 2029265..2029786 - 522 WP_002916308.1 flavodoxin FldB -
K8U55_RS09935 (K8U55_09930) 2029887..2030783 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K8U55_RS09940 (K8U55_09935) 2030806..2031519 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8U55_RS09945 (K8U55_09940) 2031525..2033258 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T219190 WP_004144731.1 NZ_CP084705:2028851-2029258 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T219190 NZ_CP116197:204337-204444 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219190 WP_002916312.1 NZ_CP084705:2028604-2028870 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219190 NZ_CP116197:c204288-204225 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References