Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4160108..4160781 Replicon chromosome
Accession NC_008786
Organism Verminephrobacter eiseniae EF01-2

Toxin (Protein)


Gene name vapC Uniprot ID A1WPC2
Locus tag VEIS_RS18245 Protein ID WP_011811468.1
Coordinates 4160108..4160530 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag VEIS_RS18250 Protein ID WP_011811469.1
Coordinates 4160527..4160781 (-) Length 85 a.a.

Genomic Context

VEIS_RS18210VEIS_RS29900VEIS_RS18240VEIS_RS18220VEIS_RS18225VEIS_RS18230VEIS_RS29075VEIS_RS26830VEIS_RS18245VEIS_RS18250VEIS_RS18255VEIS_RS18260VEIS_RS18265VEIS_RS18270VEIS_RS18275VEIS_RS18280
Location: 4155727..4155993 (267 bp)
Type: Others
Protein ID: WP_086014401.1
Location: 4155990..4156640 (651 bp)
Type: Others
Protein ID: WP_041950175.1
Location: 4159041..4159919 (879 bp)
Type: Others
Protein ID: WP_011811467.1
Location: 4156873..4157160 (288 bp)
Type: Others
Protein ID: WP_049773960.1
Location: 4157476..4157703 (228 bp)
Type: Others
Protein ID: WP_198137895.1
Location: 4157690..4158175 (486 bp)
Type: Others
Protein ID: WP_198137896.1
Location: 4158277..4158708 (432 bp)
Type: Others
Protein ID: WP_011811466.1
Location: 4158733..4158912 (180 bp)
Type: Others
Protein ID: WP_157048587.1
Location: 4160108..4160530 (423 bp)
Type: Toxin
Protein ID: WP_011811468.1
Location: 4160527..4160781 (255 bp)
Type: Antitoxin
Protein ID: WP_011811469.1
Location: 4160750..4161415 (666 bp)
Type: Others
Protein ID: WP_011811470.1
Location: 4161437..4161781 (345 bp)
Type: Others
Protein ID: Protein_3878
Location: 4162162..4162854 (693 bp)
Type: Others
Protein ID: WP_011811472.1
Location: 4163057..4164205 (1149 bp)
Type: Others
Protein ID: WP_011811473.1
Location: 4164202..4164828 (627 bp)
Type: Others
Protein ID: WP_011811474.1
Location: 4164838..4165614 (777 bp)
Type: Others
Protein ID: WP_011811475.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VEIS_RS182104155727..4155993+267WP_086014401.1hypothetical protein-
VEIS_RS299004155990..4156640+651WP_041950175.1helix-turn-helix domain-containing protein-
VEIS_RS182204156873..4157160-288WP_049773960.1hypothetical protein-
VEIS_RS182254157476..4157703-228WP_198137895.1hypothetical protein-
VEIS_RS182304157690..4158175-486WP_198137896.1fatty acid desaturase-
VEIS_RS290754158277..4158708-432WP_011811466.1AMP-binding protein-
VEIS_RS268304158733..4158912-180WP_157048587.1hypothetical protein-
VEIS_RS182404159041..4159919+879WP_011811467.1LysR family transcriptional regulator-
VEIS_RS182454160108..4160530-423WP_011811468.1type II toxin-antitoxin system VapC family toxinToxin
VEIS_RS182504160527..4160781-255WP_011811469.1plasmid stabilization proteinAntitoxin
VEIS_RS182554160750..4161415-666WP_011811470.1hypothetical protein-
VEIS_RS182604161437..4161781-345Protein_3878IS21 family transposase-
VEIS_RS182654162162..4162854-693WP_011811472.1glutathione S-transferase N-terminal domain-containing protein-
VEIS_RS182704163057..4164205-1149WP_011811473.1galactonate dehydratase-
VEIS_RS182754164202..4164828-627WP_011811474.12-dehydro-3-deoxy-6-phosphogalactonate aldolase-
VEIS_RS182804164838..4165614-777WP_011811475.1SDR family oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15110.50 Da        Isoelectric Point: 5.1566

>T21919 WP_011811468.1 NC_008786:c4160530-4160108 [Verminephrobacter eiseniae EF01-2]
MILLDTNVISEPLRPSPEARVSDWIDAQPLETLYLSAMTVAELRAGVALMPTGKRRTALHEHLQKRVLPMFAGRVLPFDL
ACTSAYAELMAKVRKAGIGIETADACIAAVAFANGFTVATRDTSPFQAAGLDVINPWEDA

Download         Length: 423 bp

>T21919 NC_008786:c4160530-4160108 [Verminephrobacter eiseniae EF01-2]
ATGATCCTGCTTGATACGAACGTCATTTCGGAGCCGCTGCGCCCATCGCCAGAGGCTCGCGTCAGTGACTGGATCGACGC
GCAGCCGTTGGAAACGCTGTACCTGTCGGCGATGACTGTGGCCGAACTGCGCGCCGGTGTCGCGCTGATGCCGACCGGCA
AGCGCCGGACGGCGCTGCATGAGCATCTGCAAAAGCGCGTTCTGCCGATGTTCGCGGGGCGCGTTCTGCCTTTCGATCTG
GCTTGCACAAGCGCCTATGCCGAGCTGATGGCGAAGGTTCGCAAGGCAGGCATCGGCATCGAGACTGCCGATGCCTGCAT
CGCAGCAGTCGCCTTTGCCAACGGATTTACCGTTGCTACACGCGACACAAGCCCTTTCCAAGCTGCCGGCTTGGACGTTA
TCAACCCTTGGGAGGACGCATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9507.99 Da        Isoelectric Point: 10.5767

>AT21919 WP_011811469.1 NC_008786:c4160781-4160527 [Verminephrobacter eiseniae EF01-2]
MPSVTVRNVPDEVHRAIRVRAARHGLSIEAEMRDILETAVKPQGRIKLGSLLSEIGRKVKLTEEEFAIFENVRDKTPARA
ARFE

Download         Length: 255 bp

>AT21919 NC_008786:c4160781-4160527 [Verminephrobacter eiseniae EF01-2]
ATGCCATCCGTTACCGTCCGAAATGTGCCTGATGAAGTGCATCGCGCTATCCGTGTGCGGGCCGCTCGACACGGCCTCAG
CATCGAGGCCGAGATGCGTGACATCCTGGAAACTGCCGTGAAGCCGCAGGGCCGGATCAAGCTGGGTTCGCTGCTGTCCG
AGATCGGCCGCAAGGTCAAGCTGACCGAAGAAGAGTTCGCCATCTTTGAGAACGTGCGCGACAAAACCCCGGCCCGTGCT
GCGAGATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA1WPC2

Antitoxin

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Source
ID
Structure
No matching records found

References