Detailed information of TA system TA021919

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4160108..4160781
• Replicon: chromosome
• Accession: NC_008786
• Organism: Verminephrobacter eiseniae EF01-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A1WPC2
• Locus tag: VEIS_RS18245
• Protein ID: WP_011811468.1
• Coordinates: 4160108..4160530 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: VEIS_RS18250
• Protein ID: WP_011811469.1
• Coordinates: 4160527..4160781 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VEIS_RS18210	4155727..4155993	+	267	WP_086014401.1	hypothetical protein	-
VEIS_RS29900	4155990..4156640	+	651	WP_041950175.1	helix-turn-helix domain-containing protein	-
VEIS_RS18220	4156873..4157160	-	288	WP_049773960.1	hypothetical protein	-
VEIS_RS18225	4157476..4157703	-	228	WP_198137895.1	hypothetical protein	-
VEIS_RS18230	4157690..4158175	-	486	WP_198137896.1	fatty acid desaturase	-
VEIS_RS29075	4158277..4158708	-	432	WP_011811466.1	AMP-binding protein	-
VEIS_RS26830	4158733..4158912	-	180	WP_157048587.1	hypothetical protein	-
VEIS_RS18240	4159041..4159919	+	879	WP_011811467.1	LysR family transcriptional regulator	-
VEIS_RS18245	4160108..4160530	-	423	WP_011811468.1	type II toxin-antitoxin system VapC family toxin	Toxin
VEIS_RS18250	4160527..4160781	-	255	WP_011811469.1	plasmid stabilization protein	Antitoxin
VEIS_RS18255	4160750..4161415	-	666	WP_011811470.1	hypothetical protein	-
VEIS_RS18260	4161437..4161781	-	345	Protein_3878	IS21 family transposase	-
VEIS_RS18265	4162162..4162854	-	693	WP_011811472.1	glutathione S-transferase N-terminal domain-containing protein	-
VEIS_RS18270	4163057..4164205	-	1149	WP_011811473.1	galactonate dehydratase	-
VEIS_RS18275	4164202..4164828	-	627	WP_011811474.1	2-dehydro-3-deoxy-6-phosphogalactonate aldolase	-
VEIS_RS18280	4164838..4165614	-	777	WP_011811475.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15110.50 Da
• Isoelectric Point: 5.1566

>T21919 WP_011811468.1 NC_008786:c4160530-4160108 [Verminephrobacter eiseniae EF01-2]
MILLDTNVISEPLRPSPEARVSDWIDAQPLETLYLSAMTVAELRAGVALMPTGKRRTALHEHLQKRVLPMFAGRVLPFDL
ACTSAYAELMAKVRKAGIGIETADACIAAVAFANGFTVATRDTSPFQAAGLDVINPWEDA

Nucleotide

• Length: 423 bp

>T21919 NC_008786:c4160530-4160108 [Verminephrobacter eiseniae EF01-2]
ATGATCCTGCTTGATACGAACGTCATTTCGGAGCCGCTGCGCCCATCGCCAGAGGCTCGCGTCAGTGACTGGATCGACGC
GCAGCCGTTGGAAACGCTGTACCTGTCGGCGATGACTGTGGCCGAACTGCGCGCCGGTGTCGCGCTGATGCCGACCGGCA
AGCGCCGGACGGCGCTGCATGAGCATCTGCAAAAGCGCGTTCTGCCGATGTTCGCGGGGCGCGTTCTGCCTTTCGATCTG
GCTTGCACAAGCGCCTATGCCGAGCTGATGGCGAAGGTTCGCAAGGCAGGCATCGGCATCGAGACTGCCGATGCCTGCAT
CGCAGCAGTCGCCTTTGCCAACGGATTTACCGTTGCTACACGCGACACAAGCCCTTTCCAAGCTGCCGGCTTGGACGTTA
TCAACCCTTGGGAGGACGCATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9507.99 Da
• Isoelectric Point: 10.5767

>AT21919 WP_011811469.1 NC_008786:c4160781-4160527 [Verminephrobacter eiseniae EF01-2]
MPSVTVRNVPDEVHRAIRVRAARHGLSIEAEMRDILETAVKPQGRIKLGSLLSEIGRKVKLTEEEFAIFENVRDKTPARA
ARFE

Nucleotide

• Length: 255 bp

>AT21919 NC_008786:c4160781-4160527 [Verminephrobacter eiseniae EF01-2]
ATGCCATCCGTTACCGTCCGAAATGTGCCTGATGAAGTGCATCGCGCTATCCGTGTGCGGGCCGCTCGACACGGCCTCAG
CATCGAGGCCGAGATGCGTGACATCCTGGAAACTGCCGTGAAGCCGCAGGGCCGGATCAAGCTGGGTTCGCTGCTGTCCG
AGATCGGCCGCAAGGTCAAGCTGACCGAAGAAGAGTTCGCCATCTTTGAGAACGTGCGCGACAAAACCCCGGCCCGTGCT
GCGAGATTTGAATGA

Structures

Toxin

• AlphaFold DB: A1WPC2