Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 588635..589151 Replicon chromosome
Accession NZ_CP084705
Organism Klebsiella pneumoniae strain KP1064WHY

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K8U55_RS02790 Protein ID WP_002886902.1
Coordinates 588635..588919 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K8U55_RS02795 Protein ID WP_002886901.1
Coordinates 588909..589151 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8U55_RS02765 (K8U55_02765) 584119..584382 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K8U55_RS02770 (K8U55_02770) 584512..584685 + 174 WP_002886906.1 hypothetical protein -
K8U55_RS02775 (K8U55_02775) 584688..585431 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K8U55_RS02780 (K8U55_02780) 585788..587926 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K8U55_RS02785 (K8U55_02785) 588167..588631 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K8U55_RS02790 (K8U55_02790) 588635..588919 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8U55_RS02795 (K8U55_02795) 588909..589151 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K8U55_RS02800 (K8U55_02800) 589229..591139 - 1911 WP_004152270.1 PRD domain-containing protein -
K8U55_RS02805 (K8U55_02805) 591162..592316 - 1155 WP_002886900.1 lactonase family protein -
K8U55_RS02810 (K8U55_02810) 592382..593122 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T219184 WP_002886902.1 NZ_CP084705:c588919-588635 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T219184 NZ_CP116194:4934886-4935197 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219184 WP_002886901.1 NZ_CP084705:c589151-588909 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219184 NZ_CP116194:4935198-4935488 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGTACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References