Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 3842465..3843144 | Replicon | chromosome |
| Accession | NC_008786 | ||
| Organism | Verminephrobacter eiseniae EF01-2 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A1WNI8 |
| Locus tag | VEIS_RS16845 | Protein ID | WP_011811187.1 |
| Coordinates | 3842465..3842890 (-) | Length | 142 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A1WNI9 |
| Locus tag | VEIS_RS16850 | Protein ID | WP_011811188.1 |
| Coordinates | 3842887..3843144 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VEIS_RS16810 | 3837825..3838499 | + | 675 | WP_049773948.1 | retroviral-like aspartic protease family protein | - |
| VEIS_RS16815 | 3838508..3839500 | + | 993 | WP_011811179.1 | hypothetical protein | - |
| VEIS_RS16820 | 3839510..3840130 | - | 621 | WP_041950963.1 | glycerol-3-phosphate 1-O-acyltransferase PlsY | - |
| VEIS_RS29830 | 3840508..3840786 | - | 279 | WP_198137881.1 | replication initiator protein A | - |
| VEIS_RS29835 | 3840750..3841169 | - | 420 | WP_011811182.1 | replication initiator protein A | - |
| VEIS_RS16830 | 3841239..3841589 | + | 351 | WP_011811183.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VEIS_RS16835 | 3841586..3841879 | + | 294 | WP_041950120.1 | XRE family transcriptional regulator | - |
| VEIS_RS28940 | 3841890..3842036 | - | 147 | WP_157048554.1 | hypothetical protein | - |
| VEIS_RS28945 | 3842040..3842198 | - | 159 | WP_157048555.1 | hypothetical protein | - |
| VEIS_RS16840 | 3842292..3842483 | - | 192 | WP_041950121.1 | hypothetical protein | - |
| VEIS_RS16845 | 3842465..3842890 | - | 426 | WP_011811187.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| VEIS_RS16850 | 3842887..3843144 | - | 258 | WP_011811188.1 | plasmid stability protein stbC | Antitoxin |
| VEIS_RS16855 | 3843334..3844395 | - | 1062 | WP_011811189.1 | aldo/keto reductase | - |
| VEIS_RS16860 | 3844778..3845959 | - | 1182 | WP_011811190.1 | cystathionine beta-lyase | - |
| VEIS_RS16865 | 3845988..3846716 | - | 729 | WP_011811191.1 | amino acid ABC transporter ATP-binding protein | - |
| VEIS_RS16870 | 3846713..3847462 | - | 750 | WP_011811192.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 15336.59 Da Isoelectric Point: 4.5626
>T21918 WP_011811187.1 NC_008786:c3842890-3842465 [Verminephrobacter eiseniae EF01-2]
MIVLDTNVISELWKVNPDSNVLAWIDAQAIETLYLSAVTVAELRYGLATMPEGKRRTIYQQRLEDEVLPNFAGRVLAFDL
DMSKTYAELMARARAGGKAIAKADGYIAATAAAHGLIVATRDTSPFEAGGLQVIDPWEALP
MIVLDTNVISELWKVNPDSNVLAWIDAQAIETLYLSAVTVAELRYGLATMPEGKRRTIYQQRLEDEVLPNFAGRVLAFDL
DMSKTYAELMARARAGGKAIAKADGYIAATAAAHGLIVATRDTSPFEAGGLQVIDPWEALP
Download Length: 426 bp
>T21918 NC_008786:c3842890-3842465 [Verminephrobacter eiseniae EF01-2]
ATGATCGTCCTCGATACCAACGTCATTTCCGAGTTGTGGAAGGTTAACCCGGATTCCAACGTGCTGGCGTGGATCGATGC
TCAGGCTATTGAAACGCTCTATCTGTCTGCCGTTACGGTCGCAGAGCTGCGCTATGGCCTTGCGACGATGCCCGAGGGCA
AGCGCCGCACGATCTACCAACAACGGCTAGAGGATGAGGTTTTGCCGAACTTCGCCGGCCGCGTGCTGGCCTTCGACCTG
GACATGTCCAAGACCTATGCCGAGCTGATGGCGCGGGCCAGGGCAGGGGGCAAAGCCATCGCCAAGGCAGACGGCTACAT
CGCGGCCACGGCCGCCGCGCACGGCCTGATAGTGGCGACACGCGACACCAGCCCATTTGAGGCCGGAGGGCTTCAGGTCA
TCGACCCTTGGGAGGCTTTGCCGTGA
ATGATCGTCCTCGATACCAACGTCATTTCCGAGTTGTGGAAGGTTAACCCGGATTCCAACGTGCTGGCGTGGATCGATGC
TCAGGCTATTGAAACGCTCTATCTGTCTGCCGTTACGGTCGCAGAGCTGCGCTATGGCCTTGCGACGATGCCCGAGGGCA
AGCGCCGCACGATCTACCAACAACGGCTAGAGGATGAGGTTTTGCCGAACTTCGCCGGCCGCGTGCTGGCCTTCGACCTG
GACATGTCCAAGACCTATGCCGAGCTGATGGCGCGGGCCAGGGCAGGGGGCAAAGCCATCGCCAAGGCAGACGGCTACAT
CGCGGCCACGGCCGCCGCGCACGGCCTGATAGTGGCGACACGCGACACCAGCCCATTTGAGGCCGGAGGGCTTCAGGTCA
TCGACCCTTGGGAGGCTTTGCCGTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9514.78 Da Isoelectric Point: 6.9910
>AT21918 WP_011811188.1 NC_008786:c3843144-3842887 [Verminephrobacter eiseniae EF01-2]
MANVHVRNLPDAVHRALRVRAAHHGRSTEAEIRDILEIATRPPERVKLGSLLASIAREAGGLTDEEHALFESVRDRTPAE
PMRFE
MANVHVRNLPDAVHRALRVRAAHHGRSTEAEIRDILEIATRPPERVKLGSLLASIAREAGGLTDEEHALFESVRDRTPAE
PMRFE
Download Length: 258 bp
>AT21918 NC_008786:c3843144-3842887 [Verminephrobacter eiseniae EF01-2]
ATGGCAAACGTACATGTAAGAAACCTGCCTGATGCCGTGCACCGTGCGCTTCGCGTGCGTGCCGCACATCATGGCCGCAG
CACAGAGGCGGAAATCCGCGACATTCTGGAAATCGCCACCCGGCCGCCCGAGCGCGTCAAGCTGGGTTCCTTGTTGGCAT
CCATCGCCCGCGAGGCGGGCGGCCTGACAGATGAAGAACACGCCCTGTTTGAGAGCGTGCGTGACAGGACGCCGGCCGAG
CCGATGAGGTTTGAATGA
ATGGCAAACGTACATGTAAGAAACCTGCCTGATGCCGTGCACCGTGCGCTTCGCGTGCGTGCCGCACATCATGGCCGCAG
CACAGAGGCGGAAATCCGCGACATTCTGGAAATCGCCACCCGGCCGCCCGAGCGCGTCAAGCTGGGTTCCTTGTTGGCAT
CCATCGCCCGCGAGGCGGGCGGCCTGACAGATGAAGAACACGCCCTGTTTGAGAGCGTGCGTGACAGGACGCCGGCCGAG
CCGATGAGGTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|