Detailed information of TA system TA219179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2622934..2623490
• Replicon: chromosome
• Accession: NZ_CP084704
• Organism: Desulfurispirillum indicum strain A2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGV61_RS11930
• Protein ID: WP_226508101.1
• Coordinates: 2623179..2623490 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E6W3N5
• Locus tag: LGV61_RS11925
• Protein ID: WP_013506793.1
• Coordinates: 2622934..2623191 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGV61_RS11900 (LGV61_11895)	2618019..2620190	+	2172	WP_226508096.1	SEC-C metal-binding domain-containing protein	-
LGV61_RS11905 (LGV61_11900)	2620318..2620731	+	414	WP_226508097.1	hypothetical protein	-
LGV61_RS11910 (LGV61_11905)	2620886..2621098	+	213	WP_226508098.1	hypothetical protein	-
LGV61_RS11915 (LGV61_11910)	2621062..2621874	+	813	WP_226508099.1	hypothetical protein	-
LGV61_RS11920 (LGV61_11915)	2622008..2622676	+	669	WP_226508100.1	HNH endonuclease	-
LGV61_RS11925 (LGV61_11920)	2622934..2623191	+	258	WP_013506793.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LGV61_RS11930 (LGV61_11925)	2623179..2623490	+	312	WP_226508101.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGV61_RS11935 (LGV61_11930)	2624359..2625279	+	921	WP_226508102.1	hypothetical protein	-
LGV61_RS11940 (LGV61_11935)	2625686..2627251	-	1566	WP_226508103.1	PepSY-associated TM helix domain-containing protein	-
LGV61_RS11945 (LGV61_11940)	2627405..2627881	+	477	WP_226508104.1	hypothetical protein	-
LGV61_RS11950 (LGV61_11945)	2628009..2628371	+	363	WP_226508105.1	PilZ domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2614867..2625279	10412
	-	inside	Integron	-	-	2618019..2624005	5986

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11779.55 Da
• Isoelectric Point: 4.7210

>T219179 WP_226508101.1 NZ_CP084704:2623179-2623490 [Desulfurispirillum indicum]
VAEIVWTDPALDQLEEIADYIALDKPEAAAGHVKKIFSTVDRLGQFPDSGHVPPEIPGSIYREISVRPCRIFYRQDKGVV
FIVHVMREEMLLRKFLLDEELNS

Nucleotide

• Length: 312 bp

>T219179 NZ_CP116194:c3608119-3607784 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9834.40 Da
• Isoelectric Point: 9.5940

>AT219179 WP_013506793.1 NZ_CP084704:2622934-2623191 [Desulfurispirillum indicum]
MKVELVTNLKRQATKILADLHESKEAVLITEHGQPSAYLVDVQDYEFMQRRLALLEGLSKGERAILEGRTTSHEKAKERM
QKWLK

Nucleotide

• Length: 258 bp

>AT219179 NZ_CP116194:c3608367-3608119 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: E6W3N5