Detailed information of TA system TA219178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2616062..2616646
• Replicon: chromosome
• Accession: NZ_CP084704
• Organism: Desulfurispirillum indicum strain A2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LGV61_RS11880
• Protein ID: WP_226508093.1
• Coordinates: 2616062..2616244 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LGV61_RS11885
• Protein ID: WP_226508094.1
• Coordinates: 2616254..2616646 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGV61_RS11860 (LGV61_11855)	2612923..2614137	-	1215	WP_226508089.1	ISL3 family transposase	-
LGV61_RS11865 (LGV61_11860)	2614185..2614757	+	573	WP_226508090.1	hypothetical protein	-
LGV61_RS11870 (LGV61_11865)	2614867..2615478	+	612	WP_226508091.1	LysE family transporter	-
LGV61_RS11875 (LGV61_11870)	2615582..2615767	+	186	WP_226508092.1	hypothetical protein	-
LGV61_RS11880 (LGV61_11875)	2616062..2616244	+	183	WP_226508093.1	type II toxin-antitoxin system HicA family toxin	Toxin
LGV61_RS11885 (LGV61_11880)	2616254..2616646	+	393	WP_226508094.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LGV61_RS11895 (LGV61_11890)	2617072..2617362	+	291	WP_226508095.1	helix-turn-helix domain-containing protein	-
LGV61_RS11900 (LGV61_11895)	2618019..2620190	+	2172	WP_226508096.1	SEC-C metal-binding domain-containing protein	-
LGV61_RS11905 (LGV61_11900)	2620318..2620731	+	414	WP_226508097.1	hypothetical protein	-
LGV61_RS11910 (LGV61_11905)	2620886..2621098	+	213	WP_226508098.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2614867..2625279	10412
	-	inside	Integron	-	-	2618019..2624005	5986

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-125)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6931.90 Da
• Isoelectric Point: 10.6643

>T219178 WP_226508093.1 NZ_CP084704:2616062-2616244 [Desulfurispirillum indicum]
MNSRQLIKQLEEDDWFLARVKGSHHQFKHQTKPGLVTVKHPDSDIPAGTLNNIRKQAGWK

Nucleotide

• Length: 183 bp

>T219178 NZ_CP116194:c2840208-2839957 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14141.89 Da
• Isoelectric Point: 4.9316

>AT219178 WP_226508094.1 NZ_CP084704:2616254-2616646 [Desulfurispirillum indicum]
MRFPVVLHTDDGVRFGVTVPDLPGCYSAGDTFDAALDSVLEAIDLHLEGLTEDGADIPIPRPIAEHRTNHDFADGVWAAV
DVDISRFEGRSEKINITLPRRLLAKIDSYANAHGKSRSGFLAEAARAAMR

Nucleotide

• Length: 393 bp

>AT219178 NZ_CP116194:c2839960-2839706 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA