Detailed information of TA system TA219177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2417906..2418546
• Replicon: chromosome
• Accession: NZ_CP084704
• Organism: Desulfurispirillum indicum strain A2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LGV61_RS10980
• Protein ID: WP_226507995.1
• Coordinates: 2417906..2418313 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LGV61_RS10985
• Protein ID: WP_226507996.1
• Coordinates: 2418313..2418546 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGV61_RS10980 (LGV61_10975)	2417906..2418313	-	408	WP_226507995.1	tRNA(fMet)-specific endonuclease VapC	Toxin
LGV61_RS10985 (LGV61_10980)	2418313..2418546	-	234	WP_226507996.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LGV61_RS10990 (LGV61_10985)	2419284..2419994	-	711	WP_013506882.1	anaerobic ribonucleoside-triphosphate reductase activating protein	-
LGV61_RS10995 (LGV61_10990)	2419991..2420164	-	174	WP_013506883.1	anaerobic ribonucleoside-triphosphate reductase	-
LGV61_RS11000 (LGV61_10995)	2420161..2422227	-	2067	WP_226507997.1	ribonucleoside triphosphate reductase	-
LGV61_RS11005 (LGV61_11000)	2422699..2423196	+	498	WP_013506885.1	bacterioferritin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2355721..2471075	115354

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (9-54)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15130.52 Da
• Isoelectric Point: 7.5206

>T219177 WP_226507995.1 NZ_CP084704:c2418313-2417906 [Desulfurispirillum indicum]
MLRYLLDTSIVIYVIKRRPIELLGKFNEETGRMAISSITLAELMHGVEKSAQPTKNLQHVEDFISRLEVLPYAAAAAVHY
GHIRATLERQGIPIGSNDLHIAAHSRSAGLILVTNNVREFERVPGLLYENWLTGL

Nucleotide

• Length: 408 bp

>T219177 NZ_CP116194:c2839960-2839706 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8804.66 Da
• Isoelectric Point: 4.8041

>AT219177 WP_226507996.1 NZ_CP084704:c2418546-2418313 [Desulfurispirillum indicum]
MATGTVFENNRTQAVRLPAETRFPEGVKKVHIRVHGNERILSPQNAAWDSFFNASENVSDDFMEERASQSPQEREEL

Nucleotide

• Length: 234 bp

>AT219177 NZ_CP116194:c2840208-2839957 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA