Detailed information of TA system TA219176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1071014..1071548
• Replicon: chromosome
• Accession: NZ_CP084704
• Organism: Desulfurispirillum indicum strain A2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGV61_RS05040
• Protein ID: WP_226508833.1
• Coordinates: 1071014..1071313 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E6W359
• Locus tag: LGV61_RS05045
• Protein ID: WP_013505603.1
• Coordinates: 1071303..1071548 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGV61_RS05010 (LGV61_05005)	1066080..1066685	+	606	WP_226508827.1	hypothetical protein	-
LGV61_RS05015 (LGV61_05010)	1066765..1067247	+	483	WP_226508828.1	hypothetical protein	-
LGV61_RS05020 (LGV61_05015)	1067485..1067958	+	474	WP_226508829.1	hypothetical protein	-
LGV61_RS05025 (LGV61_05020)	1068423..1069052	-	630	WP_226508830.1	LysE family translocator	-
LGV61_RS05030 (LGV61_05025)	1069568..1069864	+	297	WP_226508831.1	N(2)-fixation sustaining protein CowN	-
LGV61_RS05035 (LGV61_05030)	1069988..1070794	-	807	WP_226508832.1	class I SAM-dependent methyltransferase	-
LGV61_RS05040 (LGV61_05035)	1071014..1071313	-	300	WP_226508833.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGV61_RS05045 (LGV61_05040)	1071303..1071548	-	246	WP_013505603.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LGV61_RS05050 (LGV61_05045)	1071728..1072909	+	1182	WP_226508834.1	NAD(P)/FAD-dependent oxidoreductase	-
LGV61_RS05055 (LGV61_05050)	1073412..1073783	+	372	WP_226508835.1	hypothetical protein	-
LGV61_RS05060 (LGV61_05055)	1073682..1074047	-	366	WP_264180151.1	KilA-N domain-containing protein	-
LGV61_RS05065 (LGV61_05060)	1074140..1075150	-	1011	WP_226508836.1	virulence RhuM family protein	-
LGV61_RS05070 (LGV61_05065)	1075338..1075922	-	585	WP_226508837.1	hypothetical protein	-
LGV61_RS05075 (LGV61_05070)	1075986..1076486	-	501	Protein_994	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1059319..1075922	16603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-71)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11410.30 Da
• Isoelectric Point: 10.5021

>T219176 WP_226508833.1 NZ_CP084704:c1071313-1071014 [Desulfurispirillum indicum]
MTYKLRFHEKALAEWRALDNSIREPLKRKLASRLQQPHVPADALSGMPNCYKIKLKRIGYRLVYQVCNDTVVVSVIAVGK
RDKNHVYGSTNTRLETDKP

Nucleotide

• Length: 300 bp

>T219176 NZ_CP116194:c2607707-2607605 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9361.63 Da
• Isoelectric Point: 4.1528

>AT219176 WP_013505603.1 NZ_CP084704:c1071548-1071303 [Desulfurispirillum indicum]
MESILADATVSVTELKRSYAEILRKAEDFPVAILNHNRPEAYLLPAAYYERLLERLEDIEDALLIRERQEGPFIEVSLDD
L

Nucleotide

• Length: 246 bp

>AT219176 NZ_CP116194:2607567-2607835 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: E6W359