Detailed information of TA system TA219175

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 904813..906332
• Replicon: chromosome
• Accession: NZ_CP084704
• Organism: Desulfurispirillum indicum strain A2

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: LGV61_RS04285
• Protein ID: WP_226508766.1
• Coordinates: 905406..906332 (+)
• Length: 309 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: LGV61_RS04280
• Protein ID: WP_226508765.1
• Coordinates: 904813..905409 (+)
• Length: 199 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGV61_RS04260 (LGV61_04255)	902499..902780	+	282	WP_226508761.1	hypothetical protein	-
LGV61_RS04265 (LGV61_04260)	902820..903125	+	306	WP_226508762.1	hypothetical protein	-
LGV61_RS04270 (LGV61_04265)	903152..903430	+	279	WP_226508763.1	hypothetical protein	-
LGV61_RS04275 (LGV61_04270)	904441..904686	+	246	WP_226508764.1	hypothetical protein	-
LGV61_RS04280 (LGV61_04275)	904813..905409	+	597	WP_226508765.1	AbiEi antitoxin N-terminal domain-containing protein	Antitoxin
LGV61_RS04285 (LGV61_04280)	905406..906332	+	927	WP_226508766.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LGV61_RS04290 (LGV61_04285)	906498..906743	+	246	WP_226508767.1	hypothetical protein	-
LGV61_RS04295 (LGV61_04290)	907013..907258	+	246	WP_226508768.1	hypothetical protein	-
LGV61_RS04300 (LGV61_04295)	907404..908165	-	762	WP_013505547.1	TlyA family RNA methyltransferase	-
LGV61_RS04305 (LGV61_04300)	908162..908566	-	405	WP_226508769.1	ATP-binding protein	-
LGV61_RS04310 (LGV61_04305)	908570..909904	-	1335	WP_226508770.1	phenylacetate--CoA ligase	-
LGV61_RS04315 (LGV61_04310)	910275..911210	+	936	WP_013505544.1	DUF2232 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	890001..906332	16331

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-266)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-52)

Sequences

Toxin

Protein

• Length: 309 a.a.
• Molecular weight: 35039.21 Da
• Isoelectric Point: 5.0721

>T219175 WP_226508766.1 NZ_CP084704:905406-906332 [Desulfurispirillum indicum]
MSQDKKGNIAHSISQRLLNRAKANKEDFNFLLSRYGMERFLYRISISPHADRLILKGASLFLVWAGQNHRVSRDVDFLGF
GNPDADQLAEIFLDVCCIESPDDGMIYLCDSLKTEAICEGQEYDGVRITLVGLLDRARIPLQFDIGFGDIVTPAPENVEY
PVLLDYPPPLLRAYPRYTLVAEKTEAMVRLGLANSRLKDFYDIWLVSRLFSFEGSILQKALQNTFERRRTALPESIPFAF
TPAFYDDAQKRIQWTAFVKKSKPSIPIYDLTTIITDISDFLVPVVKGLLLNDPFECTWLPDHGWSGES

Nucleotide

• Length: 927 bp

>T219175 NZ_CP116194:c2272757-2272479 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 199 a.a.
• Molecular weight: 22310.96 Da
• Isoelectric Point: 8.4433

>AT219175 WP_226508765.1 NZ_CP084704:904813-905409 [Desulfurispirillum indicum]
MSRRHQILELVSKKGIIRAEDVEAMGISRNYLFWMHREGYLERIAVGVYALPDAPVSEGSTLAEVATRMPRAVVCLVSAL
NFHGITSQLSPEIWLTIPRGSWKPDMQYPPLNLTYVSEPAYSFGIQEHVVNGVLVKVYSPAKTVADCFKFRSKVGLDIAI
EGLREAWRSRKVTMDELMEAAEVNRVSKVMRPYLEAVV

Nucleotide

• Length: 597 bp

>AT219175 NZ_CP116194:c2272479-2272195 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA