Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 3728776..3729329 | Replicon | chromosome |
| Accession | NC_008786 | ||
| Organism | Verminephrobacter eiseniae EF01-2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | VEIS_RS16275 | Protein ID | WP_011811071.1 |
| Coordinates | 3728776..3729069 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A1WN73 |
| Locus tag | VEIS_RS16280 | Protein ID | WP_011811072.1 |
| Coordinates | 3729057..3729329 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VEIS_RS16230 | 3723820..3724167 | - | 348 | WP_011811061.1 | helix-turn-helix domain-containing protein | - |
| VEIS_RS26600 | 3724133..3724529 | - | 397 | Protein_3440 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VEIS_RS27800 | 3724631..3724795 | - | 165 | Protein_3441 | Hin recombinase | - |
| VEIS_RS27805 | 3724796..3724945 | - | 150 | WP_086014399.1 | replication initiation protein | - |
| VEIS_RS16240 | 3725209..3725472 | + | 264 | WP_041950935.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| VEIS_RS16245 | 3725459..3725761 | + | 303 | WP_011811064.1 | type II toxin-antitoxin system YafQ family toxin | - |
| VEIS_RS16250 | 3726051..3726560 | + | 510 | Protein_3445 | Tn3 family transposase | - |
| VEIS_RS16255 | 3726595..3726976 | + | 382 | Protein_3446 | hypothetical protein | - |
| VEIS_RS16260 | 3727050..3727382 | + | 333 | WP_083758754.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VEIS_RS16265 | 3727379..3727690 | + | 312 | WP_011811068.1 | putative addiction module antidote protein | - |
| VEIS_RS29795 | 3728049..3728234 | - | 186 | Protein_3449 | hypothetical protein | - |
| VEIS_RS29800 | 3728217..3728363 | - | 147 | Protein_3450 | addiction module antidote protein | - |
| VEIS_RS26615 | 3728391..3728606 | - | 216 | Protein_3451 | transcriptional regulator | - |
| VEIS_RS28900 | 3728603..3728776 | - | 174 | WP_011811070.1 | hypothetical protein | - |
| VEIS_RS16275 | 3728776..3729069 | - | 294 | WP_011811071.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VEIS_RS16280 | 3729057..3729329 | - | 273 | WP_011811072.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| VEIS_RS16285 | 3729520..3730227 | + | 708 | Protein_3455 | recombinase family protein | - |
| VEIS_RS29805 | 3730234..3730425 | + | 192 | WP_198138058.1 | hypothetical protein | - |
| VEIS_RS16290 | 3730493..3731124 | + | 632 | Protein_3457 | ParA family protein | - |
| VEIS_RS16295 | 3731117..3731446 | + | 330 | WP_011811074.1 | hypothetical protein | - |
| VEIS_RS16300 | 3731558..3731893 | - | 336 | Protein_3459 | integrase | - |
| VEIS_RS16305 | 3731895..3732440 | + | 546 | Protein_3460 | site-specific integrase | - |
| VEIS_RS16310 | 3732747..3733808 | + | 1062 | WP_011811077.1 | IS630 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3708468..3738897 | 30429 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 10702.20 Da Isoelectric Point: 5.6218
>T21917 WP_011811071.1 NC_008786:c3729069-3728776 [Verminephrobacter eiseniae EF01-2]
VPQVIVTEGAAEGLERCRRFLAVKAPDAARRAGQAIERQFLLLKTAPDIGPPFPETPELRELVIAFGDSGYVALYHHEPA
DDAVYVLAFRHQKEAGY
VPQVIVTEGAAEGLERCRRFLAVKAPDAARRAGQAIERQFLLLKTAPDIGPPFPETPELRELVIAFGDSGYVALYHHEPA
DDAVYVLAFRHQKEAGY
Download Length: 294 bp
>T21917 NC_008786:c3729069-3728776 [Verminephrobacter eiseniae EF01-2]
GTGCCACAAGTAATCGTCACCGAAGGCGCGGCGGAGGGCTTGGAACGATGCCGGCGGTTCCTGGCCGTCAAGGCACCGGA
CGCCGCCAGGCGTGCCGGCCAGGCCATCGAGCGGCAATTCCTGCTGCTGAAGACGGCCCCCGACATTGGCCCGCCGTTCC
CTGAAACGCCCGAGCTGCGCGAGCTGGTGATTGCCTTCGGGGATTCCGGCTACGTGGCCCTGTACCACCACGAACCGGCC
GACGATGCTGTGTATGTTCTGGCCTTCCGGCACCAGAAAGAGGCGGGCTACTAA
GTGCCACAAGTAATCGTCACCGAAGGCGCGGCGGAGGGCTTGGAACGATGCCGGCGGTTCCTGGCCGTCAAGGCACCGGA
CGCCGCCAGGCGTGCCGGCCAGGCCATCGAGCGGCAATTCCTGCTGCTGAAGACGGCCCCCGACATTGGCCCGCCGTTCC
CTGAAACGCCCGAGCTGCGCGAGCTGGTGATTGCCTTCGGGGATTCCGGCTACGTGGCCCTGTACCACCACGAACCGGCC
GACGATGCTGTGTATGTTCTGGCCTTCCGGCACCAGAAAGAGGCGGGCTACTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10579.86 Da Isoelectric Point: 8.0869
>AT21917 WP_011811072.1 NC_008786:c3729329-3729057 [Verminephrobacter eiseniae EF01-2]
MSTSLKIDDTLKGRVQHLASQRRRSPHWIMLEAIQQYVEREEARESFKQEALASWAAYKETGRHLTGQEVRTWLNTWGTN
DERAVPECHK
MSTSLKIDDTLKGRVQHLASQRRRSPHWIMLEAIQQYVEREEARESFKQEALASWAAYKETGRHLTGQEVRTWLNTWGTN
DERAVPECHK
Download Length: 273 bp
>AT21917 NC_008786:c3729329-3729057 [Verminephrobacter eiseniae EF01-2]
ATGTCAACGTCTCTCAAGATCGACGATACGCTGAAAGGTCGCGTCCAGCACCTGGCCAGCCAGCGCCGGCGCTCACCCCA
CTGGATCATGCTCGAAGCGATCCAGCAGTACGTCGAGCGCGAAGAAGCCCGCGAGAGCTTCAAGCAGGAAGCCTTGGCAT
CCTGGGCGGCCTACAAGGAAACCGGCCGCCACCTGACCGGCCAGGAAGTTCGCACCTGGTTGAACACCTGGGGCACCAAT
GACGAAAGGGCGGTGCCTGAGTGCCACAAGTAA
ATGTCAACGTCTCTCAAGATCGACGATACGCTGAAAGGTCGCGTCCAGCACCTGGCCAGCCAGCGCCGGCGCTCACCCCA
CTGGATCATGCTCGAAGCGATCCAGCAGTACGTCGAGCGCGAAGAAGCCCGCGAGAGCTTCAAGCAGGAAGCCTTGGCAT
CCTGGGCGGCCTACAAGGAAACCGGCCGCCACCTGACCGGCCAGGAAGTTCGCACCTGGTTGAACACCTGGGGCACCAAT
GACGAAAGGGCGGTGCCTGAGTGCCACAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|