Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ParE-CopA/RHH(antitoxin) |
| Location | 2745954..2746533 | Replicon | chromosome |
| Accession | NC_008786 | ||
| Organism | Verminephrobacter eiseniae EF01-2 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | VEIS_RS29710 | Protein ID | WP_198137995.1 |
| Coordinates | 2746360..2746533 (+) | Length | 58 a.a. |
Antitoxin (Protein)
| Gene name | copA | Uniprot ID | - |
| Locus tag | VEIS_RS11885 | Protein ID | WP_011810176.1 |
| Coordinates | 2745954..2746256 (+) | Length | 101 a.a. |
Genomic Context
Location: 2745954..2746256 (303 bp)
Type: Antitoxin
Protein ID: WP_011810176.1
Type: Antitoxin
Protein ID: WP_011810176.1
Location: 2746360..2746533 (174 bp)
Type: Toxin
Protein ID: WP_198137995.1
Type: Toxin
Protein ID: WP_198137995.1
Location: 2744008..2745291 (1284 bp)
Type: Others
Protein ID: WP_011810174.1
Type: Others
Protein ID: WP_011810174.1
Location: 2745428..2745775 (348 bp)
Type: Others
Protein ID: WP_011810175.1
Type: Others
Protein ID: WP_011810175.1
Location: 2746609..2746920 (312 bp)
Type: Others
Protein ID: WP_011810178.1
Type: Others
Protein ID: WP_011810178.1
Location: 2747099..2747521 (423 bp)
Type: Others
Protein ID: WP_157048485.1
Type: Others
Protein ID: WP_157048485.1
Location: 2747533..2747640 (108 bp)
Type: Others
Protein ID: Protein_2515
Type: Others
Protein ID: Protein_2515
Location: 2747724..2748536 (813 bp)
Type: Others
Protein ID: WP_011810180.1
Type: Others
Protein ID: WP_011810180.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VEIS_RS11875 | 2744008..2745291 | - | 1284 | WP_011810174.1 | MFS transporter | - |
| VEIS_RS11880 | 2745428..2745775 | - | 348 | WP_011810175.1 | hypothetical protein | - |
| VEIS_RS11885 | 2745954..2746256 | + | 303 | WP_011810176.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| VEIS_RS29710 | 2746360..2746533 | + | 174 | WP_198137995.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VEIS_RS11895 | 2746609..2746920 | - | 312 | WP_011810178.1 | helix-turn-helix transcriptional regulator | - |
| VEIS_RS28665 | 2747099..2747521 | - | 423 | WP_157048485.1 | hypothetical protein | - |
| VEIS_RS26115 | 2747533..2747640 | - | 108 | Protein_2515 | type II toxin-antitoxin system ParD family antitoxin | - |
| VEIS_RS11900 | 2747724..2748536 | - | 813 | WP_011810180.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2739593..2747764 | 8171 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6471.47 Da Isoelectric Point: 7.2005
>T21916 WP_198137995.1 NC_008786:2746360-2746533 [Verminephrobacter eiseniae EF01-2]
VKVLGHQPGIGRPIEDMPDKFREWLVDFGDSGYVVRYRIDMGAATILAVRHQKEVGF
VKVLGHQPGIGRPIEDMPDKFREWLVDFGDSGYVVRYRIDMGAATILAVRHQKEVGF
Download Length: 174 bp
>T21916 NC_008786:2746360-2746533 [Verminephrobacter eiseniae EF01-2]
GTGAAAGTTCTTGGACATCAGCCCGGTATCGGCCGTCCCATCGAGGACATGCCCGACAAGTTCCGGGAATGGCTGGTCGA
TTTCGGCGACAGCGGCTATGTGGTGCGCTACCGCATCGACATGGGCGCCGCCACGATCCTCGCTGTGCGCCACCAAAAGG
AAGTGGGGTTCTGA
GTGAAAGTTCTTGGACATCAGCCCGGTATCGGCCGTCCCATCGAGGACATGCCCGACAAGTTCCGGGAATGGCTGGTCGA
TTTCGGCGACAGCGGCTATGTGGTGCGCTACCGCATCGACATGGGCGCCGCCACGATCCTCGCTGTGCGCCACCAAAAGG
AAGTGGGGTTCTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11583.18 Da Isoelectric Point: 6.4837
>AT21916 WP_011810176.1 NC_008786:2745954-2746256 [Verminephrobacter eiseniae EF01-2]
MPMPMTAAAIRPVSIKIDDDTKARVKRLAVARQRTAHWLMHEAITQYVEREEKREAFRQDTLKAWQEYRTTGLHVSADEA
DAWLAQLEQGKDIEPPECHV
MPMPMTAAAIRPVSIKIDDDTKARVKRLAVARQRTAHWLMHEAITQYVEREEKREAFRQDTLKAWQEYRTTGLHVSADEA
DAWLAQLEQGKDIEPPECHV
Download Length: 303 bp
>AT21916 NC_008786:2745954-2746256 [Verminephrobacter eiseniae EF01-2]
ATGCCAATGCCAATGACTGCTGCTGCCATTCGCCCTGTGTCGATCAAGATCGACGACGACACCAAGGCCCGCGTGAAACG
GTTGGCTGTTGCTCGCCAGCGCACGGCTCACTGGCTCATGCACGAGGCGATCACCCAGTACGTCGAGCGCGAGGAAAAGC
GCGAGGCATTCCGGCAGGACACACTCAAGGCATGGCAAGAGTACCGCACCACCGGGCTGCATGTGAGCGCCGACGAAGCC
GATGCGTGGCTGGCCCAGCTCGAACAGGGCAAGGACATCGAGCCACCTGAATGCCACGTCTGA
ATGCCAATGCCAATGACTGCTGCTGCCATTCGCCCTGTGTCGATCAAGATCGACGACGACACCAAGGCCCGCGTGAAACG
GTTGGCTGTTGCTCGCCAGCGCACGGCTCACTGGCTCATGCACGAGGCGATCACCCAGTACGTCGAGCGCGAGGAAAAGC
GCGAGGCATTCCGGCAGGACACACTCAAGGCATGGCAAGAGTACCGCACCACCGGGCTGCATGTGAGCGCCGACGAAGCC
GATGCGTGGCTGGCCCAGCTCGAACAGGGCAAGGACATCGAGCCACCTGAATGCCACGTCTGA