Detailed information of TA system TA021916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/RHH(antitoxin)
• Location: 2745954..2746533
• Replicon: chromosome
• Accession: NC_008786
• Organism: Verminephrobacter eiseniae EF01-2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: VEIS_RS29710
• Protein ID: WP_198137995.1
• Coordinates: 2746360..2746533 (+)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: -
• Locus tag: VEIS_RS11885
• Protein ID: WP_011810176.1
• Coordinates: 2745954..2746256 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VEIS_RS11875	2744008..2745291	-	1284	WP_011810174.1	MFS transporter	-
VEIS_RS11880	2745428..2745775	-	348	WP_011810175.1	hypothetical protein	-
VEIS_RS11885	2745954..2746256	+	303	WP_011810176.1	ribbon-helix-helix domain-containing protein	Antitoxin
VEIS_RS29710	2746360..2746533	+	174	WP_198137995.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VEIS_RS11895	2746609..2746920	-	312	WP_011810178.1	helix-turn-helix transcriptional regulator	-
VEIS_RS28665	2747099..2747521	-	423	WP_157048485.1	hypothetical protein	-
VEIS_RS26115	2747533..2747640	-	108	Protein_2515	type II toxin-antitoxin system ParD family antitoxin	-
VEIS_RS11900	2747724..2748536	-	813	WP_011810180.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2739593..2747764	8171

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-55)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-50)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6471.47 Da
• Isoelectric Point: 7.2005

>T21916 WP_198137995.1 NC_008786:2746360-2746533 [Verminephrobacter eiseniae EF01-2]
VKVLGHQPGIGRPIEDMPDKFREWLVDFGDSGYVVRYRIDMGAATILAVRHQKEVGF

Nucleotide

• Length: 174 bp

>T21916 NC_008786:2746360-2746533 [Verminephrobacter eiseniae EF01-2]
GTGAAAGTTCTTGGACATCAGCCCGGTATCGGCCGTCCCATCGAGGACATGCCCGACAAGTTCCGGGAATGGCTGGTCGA
TTTCGGCGACAGCGGCTATGTGGTGCGCTACCGCATCGACATGGGCGCCGCCACGATCCTCGCTGTGCGCCACCAAAAGG
AAGTGGGGTTCTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11583.18 Da
• Isoelectric Point: 6.4837

>AT21916 WP_011810176.1 NC_008786:2745954-2746256 [Verminephrobacter eiseniae EF01-2]
MPMPMTAAAIRPVSIKIDDDTKARVKRLAVARQRTAHWLMHEAITQYVEREEKREAFRQDTLKAWQEYRTTGLHVSADEA
DAWLAQLEQGKDIEPPECHV

Nucleotide

• Length: 303 bp

>AT21916 NC_008786:2745954-2746256 [Verminephrobacter eiseniae EF01-2]
ATGCCAATGCCAATGACTGCTGCTGCCATTCGCCCTGTGTCGATCAAGATCGACGACGACACCAAGGCCCGCGTGAAACG
GTTGGCTGTTGCTCGCCAGCGCACGGCTCACTGGCTCATGCACGAGGCGATCACCCAGTACGTCGAGCGCGAGGAAAAGC
GCGAGGCATTCCGGCAGGACACACTCAAGGCATGGCAAGAGTACCGCACCACCGGGCTGCATGTGAGCGCCGACGAAGCC
GATGCGTGGCTGGCCCAGCTCGAACAGGGCAAGGACATCGAGCCACCTGAATGCCACGTCTGA