Detailed information of TA system TA219159

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2211048..2211705
• Replicon: chromosome
• Accession: NZ_CP084692
• Organism: Enterobacter mori strain BC01

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: K6742_RS10380
• Protein ID: WP_120158689.1
• Coordinates: 2211295..2211705 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V3PWU7
• Locus tag: K6742_RS10375
• Protein ID: WP_010435322.1
• Coordinates: 2211048..2211314 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6742_RS10355 (K6742_10355)	2206481..2207914	-	1434	WP_120158687.1	6-phospho-beta-glucosidase BglA	-
K6742_RS10360 (K6742_10360)	2208032..2208763	-	732	WP_182401432.1	MurR/RpiR family transcriptional regulator	-
K6742_RS10365 (K6742_10365)	2209029..2209688	+	660	WP_182401430.1	hemolysin III family protein	-
K6742_RS10370 (K6742_10370)	2209773..2210753	-	981	WP_174340159.1	tRNA-modifying protein YgfZ	-
K6742_RS10375 (K6742_10375)	2211048..2211314	+	267	WP_010435322.1	FAD assembly factor SdhE	Antitoxin
K6742_RS10380 (K6742_10380)	2211295..2211705	+	411	WP_120158689.1	protein YgfX	Toxin
K6742_RS10385 (K6742_10385)	2211713..2212234	-	522	WP_182401426.1	flavodoxin FldB	-
K6742_RS10390 (K6742_10390)	2212336..2213232	+	897	WP_089600303.1	site-specific tyrosine recombinase XerD	-
K6742_RS10395 (K6742_10395)	2213261..2213974	+	714	WP_010435313.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
K6742_RS10400 (K6742_10400)	2213980..2215713	+	1734	WP_148400611.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16115.02 Da
• Isoelectric Point: 11.7415

>T219159 WP_120158689.1 NZ_CP084692:2211295-2211705 [Enterobacter mori]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEIVGTPWMLSVGMMLRLRQPEGGRRQHLWLAADSMDAAEWRDLRRMMLQQPTQG

Nucleotide

• Length: 411 bp

>T219159 NZ_CP116191:c4034824-4034510 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.02 Da
• Isoelectric Point: 5.1340

>AT219159 WP_010435322.1 NZ_CP084692:2211048-2211314 [Enterobacter mori]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT219159 NZ_CP116191:c4034513-4034097 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: V3PWU7