Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 206626..207246 Replicon chromosome
Accession NZ_CP084692
Organism Enterobacter mori strain BC01

Toxin (Protein)


Gene name Hha Uniprot ID V3PUI7
Locus tag K6742_RS00965 Protein ID WP_010428174.1
Coordinates 207028..207246 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag K6742_RS00960 Protein ID WP_008499288.1
Coordinates 206626..207000 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6742_RS00950 (K6742_00950) 201754..202947 + 1194 WP_120159040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K6742_RS00955 (K6742_00955) 202970..206116 + 3147 WP_089598001.1 multidrug efflux RND transporter permease subunit AcrB -
K6742_RS00960 (K6742_00960) 206626..207000 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
K6742_RS00965 (K6742_00965) 207028..207246 + 219 WP_010428174.1 HHA domain-containing protein Toxin
K6742_RS00970 (K6742_00970) 207456..208007 + 552 WP_120159039.1 maltose O-acetyltransferase -
K6742_RS00975 (K6742_00975) 208125..208592 + 468 WP_089597999.1 YlaC family protein -
K6742_RS00980 (K6742_00980) 208564..210024 - 1461 WP_214594456.1 PLP-dependent aminotransferase family protein -
K6742_RS00985 (K6742_00985) 210126..210836 + 711 WP_214594457.1 GNAT family protein -
K6742_RS00990 (K6742_00990) 210833..210973 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
K6742_RS00995 (K6742_00995) 210976..211236 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T219153 WP_010428174.1 NZ_CP084692:207028-207246 [Enterobacter mori]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T219153 NZ_CP116191:c2606374-2606272 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT219153 WP_008499288.1 NZ_CP084692:206626-207000 [Enterobacter mori]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT219153 NZ_CP116191:2606234-2606502 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V3PUI7

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References