Detailed information of TA system TA219152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4309190..4310004
• Replicon: chromosome
• Accession: NZ_CP084683
• Organism: Escherichia coli strain BL21(RP)

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: LGS58_RS20810
• Protein ID: WP_001054376.1
• Coordinates: 4309190..4309447 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: LGS58_RS20815
• Protein ID: WP_001309181.1
• Coordinates: 4309459..4310004 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGS58_RS20785 (4304478)	4304478..4305584	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
LGS58_RS20790 (4305649)	4305649..4306629	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
LGS58_RS20795 (4306739)	4306739..4306944	+	206	Protein_4112	HNH endonuclease	-
LGS58_RS20800 (4307212)	4307212..4308452	-	1241	Protein_4113	helicase YjhR	-
LGS58_RS20805 (4308568)	4308568..4308699	+	132	WP_001309182.1	hypothetical protein	-
LGS58_RS20810 (4309190)	4309190..4309447	+	258	WP_001054376.1	YjhX family toxin	Toxin
LGS58_RS20815 (4309459)	4309459..4310004	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
LGS58_RS20820 (4310060)	4310060..4310806	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
LGS58_RS20825 (4310975)	4310975..4311193	+	219	Protein_4118	hypothetical protein	-
LGS58_RS20830 (4311231)	4311231..4311347	+	117	Protein_4119	VOC family protein	-
LGS58_RS20835 (4311592)	4311592..4312713	+	1122	WP_000010829.1	M42 family metallopeptidase	-
LGS58_RS20840 (4312710)	4312710..4312988	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
LGS58_RS20845 (4313000)	4313000..4314313	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T219152 WP_001054376.1 NZ_CP084683:4309190-4309447 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T219152 NZ_CP116191:c2271424-2271146 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT219152 WP_001309181.1 NZ_CP084683:4309459-4310004 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT219152 NZ_CP116191:c2271146-2270862 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8