Detailed information of TA system TA021915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 1568472..1568935
• Replicon: chromosome
• Accession: NC_008786
• Organism: Verminephrobacter eiseniae EF01-2

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: -
• Locus tag: VEIS_RS29660
• Protein ID: WP_198137966.1
• Coordinates: 1568472..1568750 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: A1WHR5
• Locus tag: VEIS_RS06870
• Protein ID: WP_011809181.1
• Coordinates: 1568747..1568935 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VEIS_RS06830	1564478..1565035	-	558	WP_011809175.1	recombinase family protein	-
VEIS_RS06835	1565029..1565400	-	372	WP_011809176.1	hypothetical protein	-
VEIS_RS06840	1565397..1565723	-	327	WP_011809177.1	hypothetical protein	-
VEIS_RS06845	1565747..1566142	-	396	WP_011809178.1	hypothetical protein	-
VEIS_RS06850	1566306..1566683	-	378	WP_011809179.1	DUF86 domain-containing protein	-
VEIS_RS06855	1566680..1566970	-	291	WP_011809180.1	nucleotidyltransferase	-
VEIS_RS29645	1567130..1567564	+	435	Protein_1458	DUF4158 domain-containing protein	-
VEIS_RS29650	1567562..1567894	+	333	Protein_1459	Tn3 family transposase	-
VEIS_RS29655	1568142..1568414	-	273	WP_198137964.1	Fic family protein	-
VEIS_RS29660	1568472..1568750	-	279	WP_198137966.1	Fic family protein	Toxin
VEIS_RS06870	1568747..1568935	-	189	WP_011809181.1	antitoxin VbhA family protein	Antitoxin
VEIS_RS06875	1569000..1569464	-	465	WP_011809182.1	hypothetical protein	-
VEIS_RS06880	1570003..1571357	-	1355	Protein_1464	IS4 family transposase	-
VEIS_RS06885	1571635..1572546	+	912	WP_011809184.1	hypothetical protein	-
VEIS_RS06890	1572599..1572925	+	327	WP_011809185.1	type II toxin-antitoxin system PrlF family antitoxin	-
VEIS_RS06895	1572922..1573494	+	573	WP_011809186.1	type II toxin-antitoxin system YhaV family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin VbhA-like (4-57)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10411.85 Da
• Isoelectric Point: 9.5348

>T21915 WP_198137966.1 NC_008786:c1568750-1568472 [Verminephrobacter eiseniae EF01-2]
MKYAGDRGDPYLDSETGVLRNLLGIKEQGGLDKAESTLSFLRASELREQPVKGKFDLAHLQRIHKRLFGDVYDWAGQIRQ
VEISKGSTMFAR

Nucleotide

• Length: 279 bp

>T21915 NC_008786:c1568750-1568472 [Verminephrobacter eiseniae EF01-2]
ATGAAATACGCCGGGGATCGCGGCGATCCTTACCTGGACAGCGAAACGGGTGTTCTCCGCAATCTCCTTGGAATCAAGGA
ACAGGGTGGACTCGATAAAGCCGAATCCACCCTTTCCTTTTTGCGGGCCAGCGAATTGCGCGAGCAGCCCGTTAAAGGCA
AATTCGATTTAGCGCACCTGCAGCGAATTCACAAGCGCCTTTTTGGCGACGTGTACGACTGGGCGGGCCAAATCCGCCAG
GTCGAAATCTCGAAAGGCAGCACTATGTTTGCCCGGTAG

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6890.76 Da
• Isoelectric Point: 4.4982

>AT21915 WP_011809181.1 NC_008786:c1568935-1568747 [Verminephrobacter eiseniae EF01-2]
MISEQEQTERRAVVQSALASQRIEGLEPDAQAVADAERWARGEMAIGAAVDQYKARMRLEMA

Nucleotide

• Length: 189 bp

>AT21915 NC_008786:c1568935-1568747 [Verminephrobacter eiseniae EF01-2]
ATGATCTCAGAGCAGGAACAAACCGAGCGCCGCGCCGTGGTGCAAAGCGCCCTTGCGAGCCAGCGCATCGAGGGCTTGGA
GCCTGATGCACAGGCCGTGGCCGACGCCGAACGCTGGGCGCGTGGCGAGATGGCCATCGGTGCCGCCGTGGACCAGTACA
AGGCGCGCATGCGGCTAGAAATGGCATGA

Structures

Antitoxin

• AlphaFold DB: A1WHR5