Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 1748200..1748854 | Replicon | chromosome |
Accession | NZ_CP084683 | ||
Organism | Escherichia coli strain BL21(RP) |
Toxin (Protein)
Gene name | cptA | Uniprot ID | A0A140N853 |
Locus tag | LGS58_RS08515 | Protein ID | WP_000244783.1 |
Coordinates | 1748447..1748854 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | S1PPB1 |
Locus tag | LGS58_RS08510 | Protein ID | WP_000354046.1 |
Coordinates | 1748200..1748466 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LGS58_RS08485 (1743369) | 1743369..1744112 | + | 744 | WP_000951948.1 | SDR family oxidoreductase | - |
LGS58_RS08490 (1744169) | 1744169..1745602 | - | 1434 | WP_012775976.1 | 6-phospho-beta-glucosidase BglA | - |
LGS58_RS08495 (1745647) | 1745647..1745958 | + | 312 | WP_001182954.1 | N(4)-acetylcytidine aminohydrolase | - |
LGS58_RS08500 (1746122) | 1746122..1746781 | + | 660 | WP_000250274.1 | hemolysin III family protein | - |
LGS58_RS08505 (1746977) | 1746977..1747957 | - | 981 | WP_000886062.1 | tRNA-modifying protein YgfZ | - |
LGS58_RS08510 (1748200) | 1748200..1748466 | + | 267 | WP_000354046.1 | FAD assembly factor SdhE | Antitoxin |
LGS58_RS08515 (1748447) | 1748447..1748854 | + | 408 | WP_000244783.1 | protein YgfX | Toxin |
LGS58_RS08520 (1748894) | 1748894..1749415 | - | 522 | WP_001055874.1 | flavodoxin FldB | - |
LGS58_RS08525 (1749527) | 1749527..1750423 | + | 897 | WP_000806638.1 | site-specific tyrosine recombinase XerD | - |
LGS58_RS08530 (1750448) | 1750448..1751158 | + | 711 | WP_000715216.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
LGS58_RS08535 (1751164) | 1751164..1752897 | + | 1734 | WP_000813212.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15962.85 Da Isoelectric Point: 11.2669
>T219141 WP_000244783.1 NZ_CP084683:1748447-1748854 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
Download Length: 408 bp
>T219141 NZ_CP116189:73711-73860 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10547.12 Da Isoelectric Point: 5.1599
>AT219141 WP_000354046.1 NZ_CP084683:1748200-1748466 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT219141 NZ_CP116189:c73667-73606 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A140N853 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QD57 |