Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3764493..3765105 Replicon chromosome
Accession NZ_CP084664
Organism UNVERIFIED_ORG: Hafnia paralvei strain FDAARGOS_1502

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LA328_RS17570 Protein ID WP_175320659.1
Coordinates 3764493..3764672 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LA328_RS17575 Protein ID WP_175320658.1
Coordinates 3764695..3765105 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA328_RS17550 (LA328_17550) 3759831..3760937 + 1107 WP_061059545.1 transglutaminase domain-containing protein -
LA328_RS17555 (LA328_17555) 3760988..3761488 - 501 WP_226228464.1 cytochrome b/b6 domain-containing protein -
LA328_RS17560 (LA328_17560) 3761509..3761901 - 393 WP_039184830.1 cytochrome b562 -
LA328_RS17565 (LA328_17565) 3762811..3764151 - 1341 WP_008815237.1 metalloprotease PmbA -
LA328_RS17570 (LA328_17570) 3764493..3764672 + 180 WP_175320659.1 type II toxin-antitoxin system HicA family toxin Toxin
LA328_RS17575 (LA328_17575) 3764695..3765105 + 411 WP_175320658.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LA328_RS17580 (LA328_17580) 3765210..3765767 + 558 WP_039184825.1 ribosome biogenesis factor YjgA -
LA328_RS17585 (LA328_17585) 3765847..3766125 - 279 WP_039184822.1 barstar family protein -
LA328_RS17590 (LA328_17590) 3766131..3766589 - 459 WP_008815240.1 ribonuclease domain-containing protein -
LA328_RS17595 (LA328_17595) 3766849..3768339 - 1491 WP_048797737.1 NAD-dependent succinate-semialdehyde dehydrogenase -
LA328_RS17600 (LA328_17600) 3768627..3770021 - 1395 WP_175320667.1 ATP-dependent RNA helicase DbpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6538.70 Da        Isoelectric Point: 11.0776

>T219128 WP_175320659.1 NZ_CP084664:3764493-3764672 [Hafnia paralvei]
MNSGMLIAEIMADGWILKRVKGSHHHFTHPNKTGLVTIPHLKKDLPANTVKSIRQQAGL

Download         Length: 180 bp

>T219128 NZ_CP116188:c2367636-2366314 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGCTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14967.18 Da        Isoelectric Point: 4.5106

>AT219128 WP_175320658.1 NZ_CP084664:3764695-3765105 [Hafnia paralvei]
MLYPIAIESGDQHHSYGVTVPDLPGCFSAGDTLDEAIANAKQAIISHIELLVEMEADFPMPSKIEDLSNKAEYQEYIWAI
VEVDVTRLMGGAEKINVTLPKSLIARIDRVVALHPEYKSRSGFLAQAALEQVTVIK

Download         Length: 411 bp

>AT219128 NZ_CP116188:c2367902-2367636 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References