219127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3107878..3108469 Replicon chromosome
Accession NZ_CP084664
Organism UNVERIFIED_ORG: Hafnia paralvei strain FDAARGOS_1502

Toxin (Protein)


Gene name Hha Uniprot ID G9Y5B5
Locus tag LA328_RS14540 Protein ID WP_004091739.1
Coordinates 3108266..3108469 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q9EVH1
Locus tag LA328_RS14535 Protein ID WP_008814252.1
Coordinates 3107878..3108252 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA328_RS14520 (LA328_14520) 3103636..3106788 + 3153 WP_226228275.1 efflux RND transporter permease subunit -
LA328_RS14525 (LA328_14525) 3106949..3107221 + 273 WP_004091742.1 type B 50S ribosomal protein L31 -
LA328_RS14530 (LA328_14530) 3107221..3107361 + 141 WP_020303633.1 type B 50S ribosomal protein L36 -
LA328_RS14535 (LA328_14535) 3107878..3108252 + 375 WP_008814252.1 Hha toxicity modulator TomB Antitoxin
LA328_RS14540 (LA328_14540) 3108266..3108469 + 204 WP_004091739.1 HHA domain-containing protein Toxin
LA328_RS14550 (LA328_14550) 3109426..3109758 + 333 WP_070713534.1 MGMT family protein -
LA328_RS14555 (LA328_14555) 3109816..3110334 - 519 WP_008814254.1 YbaY family lipoprotein -
LA328_RS14560 (LA328_14560) 3110647..3111507 + 861 WP_008814255.1 acyl-CoA thioesterase II -
LA328_RS14565 (LA328_14565) 3111571..3112860 - 1290 WP_008814256.1 ammonium transporter AmtB -
LA328_RS14570 (LA328_14570) 3112894..3113232 - 339 WP_004091732.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8119.38 Da        Isoelectric Point: 5.8346

>T219127 WP_004091739.1 NZ_CP084664:3108266-3108469 [Hafnia paralvei]
MTKIDYLMRLRKCTTLDTLERVIEKNKYELSDDELETFYSAADHRLAELTMNKLYDKIPAEVWKYVR

Download         Length: 204 bp

>T219127 NZ_CP116188:2279142-2279318 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14447.17 Da        Isoelectric Point: 4.4776

>AT219127 WP_008814252.1 NZ_CP084664:3107878-3108252 [Hafnia paralvei]
MDEYTSYQHDITELKYLCNMLYNQGMDVLSDSHHGWVNDPTAVDNLQLNELNEHIANFGLTFKIKYPNASELTEILDEYL
DETYSLFSNYSINEPELKKWLKAKGRILRYLAGEKTTSALNFNL

Download         Length: 375 bp

>AT219127 NZ_CP116188:2279364-2279780 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G9Y5B5

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q9EVH1

References