Detailed information of TA system TA219118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataT-KacA/DUF1778(antitoxin)
• Location: 2064001..2064798
• Replicon: chromosome
• Accession: NZ_CP084664
• Organism: UNVERIFIED_ORG: Hafnia paralvei strain FDAARGOS_1502

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: LA328_RS09745
• Protein ID: WP_175319904.1
• Coordinates: 2064274..2064798 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: KacA
• Uniprot ID: A0A2A2MFP5
• Locus tag: LA328_RS09740
• Protein ID: WP_039186676.1
• Coordinates: 2064001..2064270 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA328_RS09725 (LA328_09725)	2059594..2060625	-	1032	WP_020303739.1	Mal regulon transcriptional regulator MalI	-
LA328_RS09730 (LA328_09730)	2060907..2062502	+	1596	WP_096080818.1	maltose/glucose-specific PTS transporter subunit IIBC	-
LA328_RS09735 (LA328_09735)	2062590..2063765	+	1176	WP_061060038.1	MalY/PatB family protein	-
LA328_RS09740 (LA328_09740)	2064001..2064270	+	270	WP_039186676.1	DUF1778 domain-containing protein	Antitoxin
LA328_RS09745 (LA328_09745)	2064274..2064798	+	525	WP_175319904.1	N-acetyltransferase	Toxin
LA328_RS09750 (LA328_09750)	2064980..2065978	+	999	WP_008813542.1	adenosine deaminase	-
LA328_RS09755 (LA328_09755)	2066569..2067567	-	999	WP_008813543.1	bile acid:sodium symporter family protein	-
LA328_RS09760 (LA328_09760)	2067699..2068742	-	1044	WP_008813544.1	oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (8-85)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19657.53 Da
• Isoelectric Point: 7.0494

>T219118 WP_175319904.1 NZ_CP084664:2064274-2064798 [Hafnia paralvei]
MPDLAIEIFSNDIEYDFAHFDCGEESLNIFLTNHLARQHNARILRGYLLVTKEPKPKVVGYYTLSGSCFEKETLPSNTQK
RKVPYANVPSVTLGRLAIQKELQGQDWGTTLVTHAMKVIYHASLAVGIHGMFVDALNEKAKRFYLQLGFIALTGNNANSL
FYPTKSIEKLFEDE

Nucleotide

• Length: 525 bp

>T219118 NZ_CP116184:5240-5518 [Escherichia coli]
ATGGAGATATTCTGGACCATACTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTATATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10066.50 Da
• Isoelectric Point: 7.0162

>AT219118 WP_039186676.1 NZ_CP084664:2064001-2064270 [Hafnia paralvei]
MSALKKQRIDLRLTDDDKSKIEEAAAMTNQTITQFMVASAAERAEEVIEQHRRLVLNDESWNLVMDAISNPPAPNSRLKR
AAKRLASME

Nucleotide

• Length: 270 bp

>AT219118 NZ_CP116184:4971-5240 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACTTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCCCATGATATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATAAGCAGGAAGGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2A2MFP5