Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 462269..462930 Replicon chromosome
Accession NZ_CP084664
Organism UNVERIFIED_ORG: Hafnia paralvei strain FDAARGOS_1502

Toxin (Protein)


Gene name ypjF Uniprot ID S3IMJ6
Locus tag LA328_RS02225 Protein ID WP_000698542.1
Coordinates 462607..462930 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID S3J179
Locus tag LA328_RS02220 Protein ID WP_000065326.1
Coordinates 462269..462586 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA328_RS02175 (LA328_02175) 457409..458233 + 825 WP_000197385.1 DUF932 domain-containing protein -
LA328_RS02180 (LA328_02180) 458442..459152 + 711 WP_024198336.1 hypothetical protein -
LA328_RS02185 (LA328_02185) 459178..459714 + 537 WP_000219797.1 DUF4339 domain-containing protein -
LA328_RS02190 (LA328_02190) 459756..460193 + 438 WP_024198335.1 hypothetical protein -
LA328_RS02195 (LA328_02195) 460260..460670 + 411 WP_000912997.1 hypothetical protein -
LA328_RS02200 (LA328_02200) 460748..460984 + 237 WP_000004273.1 DUF905 domain-containing protein -
LA328_RS02205 (LA328_02205) 461070..461528 + 459 WP_016538084.1 antirestriction protein -
LA328_RS02210 (LA328_02210) 461544..462020 + 477 WP_000811694.1 RadC family protein -
LA328_RS02215 (LA328_02215) 462029..462250 + 222 WP_000691995.1 DUF987 domain-containing protein -
LA328_RS02220 (LA328_02220) 462269..462586 + 318 WP_000065326.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LA328_RS02225 (LA328_02225) 462607..462930 + 324 WP_000698542.1 TA system toxin CbtA family protein Toxin
LA328_RS02230 (LA328_02230) 463273..464907 + 1635 WP_226228567.1 site-specific integrase -
LA328_RS02235 (LA328_02235) 464900..465541 + 642 WP_021563833.1 DUF4145 domain-containing protein -
LA328_RS02240 (LA328_02240) 466150..466641 + 492 WP_226228570.1 hypothetical protein -
LA328_RS02245 (LA328_02245) 466826..467299 + 474 WP_021563831.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 444006..476535 32529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.38 Da        Isoelectric Point: 8.9789

>T219117 WP_000698542.1 NZ_CP084664:462607-462930 [Hafnia paralvei]
MKILPATISRAAKPCLPPVAVWQLLLTRLLEKHYGLTLNDTPFSDETVIKEHFDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTNIDIMRARRDLGLLNRN

Download         Length: 324 bp

>T219117 NZ_CP116183:103051-103200 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11830.50 Da        Isoelectric Point: 6.9367

>AT219117 WP_000065326.1 NZ_CP084664:462269-462586 [Hafnia paralvei]
MSNIIWGLQRDITPRLGTRLVQEGNQLHYLADRACITGKFSDAECLKLDVAFPHFISRMESMLSTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYVAVYSTQR

Download         Length: 318 bp

>AT219117 NZ_CP116183:c103006-102947 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3IMJ6

Antitoxin

Source ID Structure
AlphaFold DB S3J179

References