Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 418850..419510 Replicon chromosome
Accession NZ_CP084664
Organism UNVERIFIED_ORG: Hafnia paralvei strain FDAARGOS_1502

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A2MBB6
Locus tag LA328_RS01980 Protein ID WP_008815043.1
Coordinates 419097..419510 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2A2MBZ0
Locus tag LA328_RS01975 Protein ID WP_008815042.1
Coordinates 418850..419116 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA328_RS01960 (LA328_01960) 414993..415877 + 885 WP_004846922.1 nucleoside-specific channel-forming protein Tsx -
LA328_RS01965 (LA328_01965) 416081..416905 + 825 WP_175320072.1 shikimate 5-dehydrogenase -
LA328_RS01970 (LA328_01970) 417489..418475 - 987 WP_061059196.1 tRNA-modifying protein YgfZ -
LA328_RS01975 (LA328_01975) 418850..419116 + 267 WP_008815042.1 FAD assembly factor SdhE Antitoxin
LA328_RS01980 (LA328_01980) 419097..419510 + 414 WP_008815043.1 protein YgfX Toxin
LA328_RS01985 (LA328_01985) 419559..420077 - 519 WP_114445296.1 flavodoxin FldB -
LA328_RS01990 (LA328_01990) 420282..421181 + 900 WP_061059194.1 site-specific tyrosine recombinase XerD -
LA328_RS01995 (LA328_01995) 421210..421926 + 717 WP_061059193.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA328_RS02000 (LA328_02000) 421932..423665 + 1734 WP_008815047.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16260.00 Da        Isoelectric Point: 9.1742

>T219116 WP_008815043.1 NZ_CP084664:419097-419510 [Hafnia paralvei]
VDQWRCDVRVSWRTQLLLLVTHGTLVLLILLAPWPENYSIYWLILLTLVVFESIRSQKQIAKVQGELNFLAENRISWQHQ
EWELCKTPWISDFGALLPLKSLKDQDKRKRLWIAADSLTPEAWSHLRRSLMQMRHDA

Download         Length: 414 bp

>T219116 NZ_CP116183:7974-8390 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10447.94 Da        Isoelectric Point: 5.5601

>AT219116 WP_008815042.1 NZ_CP084664:418850-419116 [Hafnia paralvei]
MDIENKSRIHWACRRGMRELDISIMPFFEHEYDSLSDTDKQTFVRLLECDDPDLFNWLMNHGSPKDPELAHMVKLIQTRN
KDRGPMAL

Download         Length: 267 bp

>AT219116 NZ_CP116183:7747-7977 [Escherichia coli]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2MBB6

Antitoxin

Source ID Structure
AlphaFold DB A0A2A2MBZ0

References