Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3738438..3739074 Replicon chromosome
Accession NZ_CP084656
Organism Pectobacterium versatile strain SR1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LGL96_RS16550 Protein ID WP_103941744.1
Coordinates 3738438..3738620 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LGL96_RS16555 Protein ID WP_103941742.1
Coordinates 3738643..3739074 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL96_RS16525 (LGL96_16525) 3733796..3733999 + 204 WP_040031402.1 YbdD/YjiX family protein -
LGL96_RS16530 (LGL96_16530) 3734016..3735002 + 987 WP_103941750.1 GTPase -
LGL96_RS16535 (LGL96_16535) 3735268..3736650 + 1383 WP_103941748.1 glycosyl hydrolase family 28 protein -
LGL96_RS16540 (LGL96_16540) 3736884..3737363 - 480 WP_005976136.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
LGL96_RS16545 (LGL96_16545) 3737434..3738252 - 819 WP_103941746.1 TraB/GumN family protein -
LGL96_RS16550 (LGL96_16550) 3738438..3738620 + 183 WP_103941744.1 type II toxin-antitoxin system HicA family toxin Toxin
LGL96_RS16555 (LGL96_16555) 3738643..3739074 + 432 WP_103941742.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LGL96_RS16560 (LGL96_16560) 3739168..3741891 - 2724 WP_225586168.1 copper-exporting P-type ATPase CopA -
LGL96_RS16565 (LGL96_16565) 3742007..3742414 + 408 WP_107332495.1 Cu(I)-responsive transcriptional regulator -
LGL96_RS16570 (LGL96_16570) 3742450..3742905 - 456 WP_107332496.1 NfeD family protein -
LGL96_RS16575 (LGL96_16575) 3742905..3743819 - 915 WP_010301277.1 SPFH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-138)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6512.68 Da        Isoelectric Point: 10.3299

>T219114 WP_103941744.1 NZ_CP084656:3738438-3738620 [Pectobacterium versatile]
MTSTDLIKELAAAGCECKRHNGGSHQIWWSPITGKTFPVPHPKKDLPLGTVKSIKKMAGI

Download         Length: 183 bp

>T219114 NZ_CP116182:c88876-88571 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16065.01 Da        Isoelectric Point: 4.3145

>AT219114 WP_103941742.1 NZ_CP084656:3738643-3739074 [Pectobacterium versatile]
MFFSVGVETPKDDATAYGLIVPVLCTDDYGCFSAADSQQEIARMAREAILTIIDEAVSRGNLDIKRLNDAGHLIYAAIPD
FADYDSWFVLDVDLSAFEGKPQRLNISLPDTLIQRIDNRVREQPGTYRDRSHFLAEAARHELE

Download         Length: 432 bp

>AT219114 NZ_CP116182:c89096-88878 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References