Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3701034..3701659 Replicon chromosome
Accession NZ_CP084656
Organism Pectobacterium versatile strain SR1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag LGL96_RS16390 Protein ID WP_005976087.1
Coordinates 3701034..3701237 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag LGL96_RS16395 Protein ID WP_005976089.1
Coordinates 3701291..3701659 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL96_RS16360 (LGL96_16360) 3696493..3696831 + 339 WP_002208627.1 P-II family nitrogen regulator -
LGL96_RS16365 (LGL96_16365) 3696871..3698157 + 1287 WP_161973278.1 ammonium transporter AmtB -
LGL96_RS16370 (LGL96_16370) 3698293..3699156 - 864 WP_225586171.1 acyl-CoA thioesterase II -
LGL96_RS16375 (LGL96_16375) 3699369..3699950 + 582 WP_225586170.1 YbaY family lipoprotein -
LGL96_RS16380 (LGL96_16380) 3699970..3700290 - 321 WP_015839360.1 MGMT family protein -
LGL96_RS16390 (LGL96_16390) 3701034..3701237 - 204 WP_005976087.1 HHA domain-containing protein Toxin
LGL96_RS16395 (LGL96_16395) 3701291..3701659 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
LGL96_RS16400 (LGL96_16400) 3702257..3702400 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
LGL96_RS16405 (LGL96_16405) 3702417..3702665 - 249 WP_039506474.1 type B 50S ribosomal protein L31 -
LGL96_RS16410 (LGL96_16410) 3702901..3706029 - 3129 WP_103941781.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T219113 WP_005976087.1 NZ_CP084656:c3701237-3701034 [Pectobacterium versatile]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T219113 NZ_CP116181:c4763752-4763441 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT219113 WP_005976089.1 NZ_CP084656:c3701659-3701291 [Pectobacterium versatile]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT219113 NZ_CP116181:c4763440-4763150 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References