Detailed information of TA system TA021911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3917942..3918634
• Replicon: chromosome
• Accession: NC_008781
• Organism: Polaromonas naphthalenivorans CJ2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A1VTK0
• Locus tag: PNAP_RS18405
• Protein ID: WP_011803044.1
• Coordinates: 3918230..3918634 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: A1VTJ9
• Locus tag: PNAP_RS18400
• Protein ID: WP_011803043.1
• Coordinates: 3917942..3918226 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PNAP_RS18390	3914029..3915252	+	1224	WP_011803041.1	ABC transporter substrate-binding protein	-
PNAP_RS18395	3915375..3917612	-	2238	WP_011803042.1	NADP-dependent isocitrate dehydrogenase	-
PNAP_RS18400	3917942..3918226	+	285	WP_011803043.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
PNAP_RS18405	3918230..3918634	+	405	WP_011803044.1	type II toxin-antitoxin system VapC family toxin	Toxin
PNAP_RS18410	3918792..3920984	-	2193	WP_011803045.1	malate synthase G	-
PNAP_RS18415	3921089..3921838	-	750	WP_011803046.1	haloacid dehalogenase type II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-116)

Antitoxin

• SpoVT-AbrB domain (6-45)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14917.15 Da
• Isoelectric Point: 8.9709

>T21911 WP_011803044.1 NC_008781:3918230-3918634 [Polaromonas naphthalenivorans CJ2]
MRYMLDTNICIYLTRHHPPQVLKRLEALAQGSAVMSVVTYAELRAGLEIQTANRQQDERVLALLISRIPVLPFTASDAES
FGRLRAAVRDRRRDAMDRLIAAHAVSVGVTLVTNNEADFNGYPGLVVENWARAA

Nucleotide

• Length: 405 bp

>T21911 NC_008781:3918230-3918634 [Polaromonas naphthalenivorans CJ2]
ATGCGCTACATGCTCGACACCAACATTTGCATCTACCTGACCAGGCACCACCCGCCGCAAGTGCTCAAACGGCTGGAAGC
CCTGGCCCAAGGCAGCGCGGTGATGTCGGTGGTCACTTATGCCGAGTTGCGCGCCGGGCTGGAGATTCAAACGGCCAACC
GTCAACAGGATGAACGTGTGCTCGCACTGCTGATAAGCCGGATTCCGGTGCTGCCATTCACCGCATCCGATGCCGAGAGT
TTTGGCCGGCTTCGCGCCGCCGTGCGCGACCGCCGCCGCGACGCCATGGACCGCCTGATTGCCGCGCATGCGGTGAGCGT
CGGTGTCACCCTCGTCACCAACAACGAGGCCGATTTCAACGGCTACCCTGGCCTGGTGGTCGAAAACTGGGCGCGCGCCG
CTTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10295.67 Da
• Isoelectric Point: 4.6510

>AT21911 WP_011803043.1 NC_008781:3917942-3918226 [Polaromonas naphthalenivorans CJ2]
MLTRVFKSGNSLAVRIPKELGFVDAAQDVEIERVGNTLVLRLVAQETLADIGEIFAMFSPSFMAEGREFHEEHERDWSGM
GLPGANAADKKTGS

Nucleotide

• Length: 285 bp

>AT21911 NC_008781:3917942-3918226 [Polaromonas naphthalenivorans CJ2]
ATGCTGACCCGAGTCTTCAAAAGCGGCAATTCGCTGGCTGTGCGTATTCCCAAGGAACTGGGCTTTGTTGACGCCGCGCA
GGATGTGGAGATCGAGCGCGTGGGAAATACGCTGGTGCTGCGCCTGGTGGCGCAGGAAACCCTGGCCGACATTGGCGAGA
TCTTTGCCATGTTCAGCCCCAGCTTCATGGCGGAGGGACGCGAATTTCATGAAGAGCATGAGCGCGACTGGAGCGGCATG
GGGCTGCCGGGCGCCAATGCAGCCGATAAAAAAACAGGAAGCTAG

Structures

Toxin

• AlphaFold DB: A1VTK0

Antitoxin

• AlphaFold DB: A1VTJ9