Detailed information of TA system TA219109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3270107..3270632
• Replicon: chromosome
• Accession: NZ_CP084656
• Organism: Pectobacterium versatile strain SR1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGL96_RS14520
• Protein ID: WP_039539560.1
• Coordinates: 3270107..3270391 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: LGL96_RS14525
• Protein ID: WP_005973616.1
• Coordinates: 3270381..3270632 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL96_RS14490 (LGL96_14490)	3265633..3266058	+	426	WP_225586039.1	hypothetical protein	-
LGL96_RS14495 (LGL96_14495)	3266308..3266790	+	483	WP_029367525.1	GNAT family N-acetyltransferase	-
LGL96_RS14500 (LGL96_14500)	3266836..3267462	-	627	WP_103861356.1	LysE family transporter	-
LGL96_RS14505 (LGL96_14505)	3267718..3268500	-	783	WP_205539329.1	transporter substrate-binding domain-containing protein	-
LGL96_RS14510 (LGL96_14510)	3268869..3269447	-	579	WP_105879156.1	hypothetical protein	-
LGL96_RS14515 (LGL96_14515)	3269665..3269841	-	177	WP_158256803.1	hypothetical protein	-
LGL96_RS14520 (LGL96_14520)	3270107..3270391	-	285	WP_039539560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGL96_RS14525 (LGL96_14525)	3270381..3270632	-	252	WP_005973616.1	prevent-host-death protein	Antitoxin
LGL96_RS14530 (LGL96_14530)	3270804..3271055	-	252	WP_223193489.1	hypothetical protein	-
LGL96_RS14535 (LGL96_14535)	3271045..3271296	-	252	WP_105879157.1	prevent-host-death protein	-
LGL96_RS14540 (LGL96_14540)	3271426..3271896	+	471	WP_103861352.1	hypothetical protein	-
LGL96_RS14545 (LGL96_14545)	3271896..3272225	+	330	WP_223193302.1	DUF1493 family protein	-
LGL96_RS14550 (LGL96_14550)	3273099..3275591	-	2493	WP_225586038.1	SIR2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11034.00 Da
• Isoelectric Point: 10.1716

>T219109 WP_039539560.1 NZ_CP084656:c3270391-3270107 [Pectobacterium versatile]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLQHPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYKTAKDRL

Nucleotide

• Length: 285 bp

>T219109 NZ_CP116181:c4162262-4161975 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT219109 WP_005973616.1 NZ_CP084656:c3270632-3270381 [Pectobacterium versatile]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT219109 NZ_CP116181:c4161988-4161686 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6