Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3035625..3036409 Replicon chromosome
Accession NZ_CP084656
Organism Pectobacterium versatile strain SR1

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LGL96_RS13450 Protein ID WP_225586371.1
Coordinates 3035915..3036409 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A855MHZ3
Locus tag LGL96_RS13445 Protein ID WP_010301483.1
Coordinates 3035625..3035918 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL96_RS13415 (LGL96_13415) 3031906..3032204 + 299 Protein_2606 ATP-binding cassette domain-containing protein -
LGL96_RS13420 (LGL96_13420) 3032194..3032421 + 228 Protein_2607 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
LGL96_RS13425 (LGL96_13425) 3032525..3033094 + 570 WP_225586369.1 ribose 1,5-bisphosphokinase -
LGL96_RS13430 (LGL96_13430) 3033133..3033918 + 786 WP_225586370.1 phosphonate metabolism protein PhnP -
LGL96_RS13435 (LGL96_13435) 3034002..3034265 - 264 WP_010286385.1 DUF2798 domain-containing protein -
LGL96_RS13440 (LGL96_13440) 3034394..3035296 + 903 WP_103164620.1 LysR family transcriptional regulator -
LGL96_RS13445 (LGL96_13445) 3035625..3035918 + 294 WP_010301483.1 DUF1778 domain-containing protein Antitoxin
LGL96_RS13450 (LGL96_13450) 3035915..3036409 + 495 WP_225586371.1 GNAT family N-acetyltransferase Toxin
LGL96_RS13455 (LGL96_13455) 3036471..3036563 + 93 Protein_2614 helix-turn-helix domain-containing protein -
LGL96_RS13465 (LGL96_13465) 3036975..3037820 + 846 WP_010301509.1 AraC family transcriptional regulator -
LGL96_RS13470 (LGL96_13470) 3037856..3038446 + 591 WP_103941983.1 LysE family translocator -
LGL96_RS13475 (LGL96_13475) 3038443..3039018 - 576 WP_040030982.1 transcriptional regulator -
LGL96_RS13480 (LGL96_13480) 3039257..3040987 - 1731 WP_103941981.1 protein-disulfide reductase DsbD -
LGL96_RS13485 (LGL96_13485) 3040963..3041295 - 333 WP_010286405.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(76-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17612.43 Da        Isoelectric Point: 8.2904

>T219107 WP_225586371.1 NZ_CP084656:3035915-3036409 [Pectobacterium versatile]
MISAPEPLHAEHVFSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDGSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVADTIGIRGVLVHALSDEARNFYLRVGFEPSPIDPMMLMVTLGDLVG
SLSI

Download         Length: 495 bp

>T219107 NZ_CP116181:c3785015-3784095 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10930.52 Da        Isoelectric Point: 10.1968

>AT219107 WP_010301483.1 NZ_CP084656:3035625-3035918 [Pectobacterium versatile]
MPVTNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT219107 NZ_CP116181:c3785784-3785002 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A855MHZ3

References