Detailed information of TA system TA219103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 2885564..2886306
• Replicon: chromosome
• Accession: NZ_CP084656
• Organism: Pectobacterium versatile strain SR1

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: LGL96_RS12800
• Protein ID: WP_039481845.1
• Coordinates: 2885564..2886043 (-)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A6P1S083
• Locus tag: LGL96_RS12805
• Protein ID: WP_039481848.1
• Coordinates: 2886034..2886306 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL96_RS12760 (LGL96_12760)	2881347..2881607	+	261	WP_039539552.1	AlpA family transcriptional regulator	-
LGL96_RS12765 (LGL96_12765)	2881604..2881828	+	225	WP_225586698.1	hypothetical protein	-
LGL96_RS22585	2881948..2882151	+	204	Protein_2477	ash family protein	-
LGL96_RS12775 (LGL96_12775)	2882187..2882384	+	198	WP_211005800.1	host cell division inhibitor Icd-like protein	-
LGL96_RS12780 (LGL96_12780)	2882377..2882571	+	195	WP_005973630.1	hypothetical protein	-
LGL96_RS12785 (LGL96_12785)	2882568..2882834	+	267	WP_116226700.1	hypothetical protein	-
LGL96_RS12790 (LGL96_12790)	2882831..2883172	+	342	WP_225586699.1	DUF5375 family protein	-
LGL96_RS12795 (LGL96_12795)	2883183..2885510	+	2328	WP_211005796.1	phage/plasmid primase, P4 family	-
LGL96_RS12800 (LGL96_12800)	2885564..2886043	-	480	WP_039481845.1	GNAT family N-acetyltransferase	Toxin
LGL96_RS12805 (LGL96_12805)	2886034..2886306	-	273	WP_039481848.1	DUF1778 domain-containing protein	Antitoxin
LGL96_RS12810 (LGL96_12810)	2886596..2886847	+	252	WP_005973616.1	prevent-host-death protein	-
LGL96_RS12815 (LGL96_12815)	2886837..2887121	+	285	WP_039534786.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LGL96_RS12820 (LGL96_12820)	2887714..2889006	+	1293	WP_225586700.1	integrase arm-type DNA-binding domain-containing protein	-
LGL96_RS12825 (LGL96_12825)	2889405..2891042	-	1638	WP_225586701.1	DNA cytosine methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2875351..2907965	32614

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (30-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-90)

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17429.04 Da
• Isoelectric Point: 8.9715

>T219103 WP_039481845.1 NZ_CP084656:c2886043-2885564 [Pectobacterium versatile]
VGITAPELLLPQHAVVDFRSSEPSLDDWLKRKALKNQTIGASRTFVVCESGANQVIGFYALATGSVQRQSVSGALRRNMP
DPLPVLVLGRLAVDERYHRRGIGAGLLKDAVLRSQQVAEQVGTKALLVHALSEEAKDFYLHWGFTSSEIQPSTLLLPLW

Nucleotide

• Length: 480 bp

>T219103 NZ_CP116181:2416421-2417743 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10288.77 Da
• Isoelectric Point: 4.7174

>AT219103 WP_039481848.1 NZ_CP084656:c2886306-2886034 [Pectobacterium versatile]
MRTEAKEAPINIRAKSSQRELIDVAAKLLSKSRTDFILEAACREAEEVLLDQRLFLVDESQFDAFITALEKPVATNERLQ
ALLDRKSPWE

Nucleotide

• Length: 273 bp

>AT219103 NZ_CP116181:2416155-2416421 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6P1S083