Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2830710..2831302 Replicon chromosome
Accession NZ_CP084656
Organism Pectobacterium versatile strain SR1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LGL96_RS12535 Protein ID WP_103971367.1
Coordinates 2830710..2830964 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LGL96_RS12540 Protein ID WP_095701362.1
Coordinates 2830961..2831302 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL96_RS12525 (LGL96_12525) 2827090..2827641 + 552 WP_095701360.1 polymer-forming cytoskeletal protein -
LGL96_RS12530 (LGL96_12530) 2827678..2830398 + 2721 WP_225586405.1 CRISPR-associated helicase Cas3' -
LGL96_RS12535 (LGL96_12535) 2830710..2830964 + 255 WP_103971367.1 type II toxin-antitoxin system HicA family toxin Toxin
LGL96_RS12540 (LGL96_12540) 2830961..2831302 + 342 WP_095701362.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LGL96_RS12545 (LGL96_12545) 2831934..2833505 + 1572 WP_180745286.1 type I-E CRISPR-associated protein Cse1/CasA -
LGL96_RS12550 (LGL96_12550) 2833489..2834136 + 648 WP_130634116.1 type I-E CRISPR-associated protein Cse2/CasB -
LGL96_RS12555 (LGL96_12555) 2834140..2835207 + 1068 WP_130637122.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
LGL96_RS12560 (LGL96_12560) 2835217..2835951 + 735 WP_103861595.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9612.09 Da        Isoelectric Point: 11.2749

>T219102 WP_103971367.1 NZ_CP084656:2830710-2830964 [Pectobacterium versatile]
MNKRHQRTLSDLFSRPVNSSIKWSDIESLFIALGAEIHEREGSRIAVLLKGEKKIFHRPHPRPTTDKGAVNSIRVWLESL
GVRP

Download         Length: 255 bp

>T219102 NZ_CP116181:2124164-2124266 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12384.98 Da        Isoelectric Point: 4.4547

>AT219102 WP_095701362.1 NZ_CP084656:2830961-2831302 [Pectobacterium versatile]
MINTLLIDGHTAVIAFDSEIEMFRGEFIGLNGGADFYAYSVDELKKEGATSLAIFLDECRRDGIEPYKSYSGKVTTRLTP
ERHAALAVTAQATGVSINELLNEGVDLVLERRS

Download         Length: 342 bp

>AT219102 NZ_CP116181:c2124304-2124036 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References