Detailed information of TA system TA219101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-DnaT
• Location: 2778453..2778984
• Replicon: chromosome
• Accession: NZ_CP084656
• Organism: Pectobacterium versatile strain SR1

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A086EVU3
• Locus tag: LGL96_RS12305
• Protein ID: WP_039282785.1
• Coordinates: 2778697..2778984 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: -
• Locus tag: LGL96_RS12300
• Protein ID: WP_039524245.1
• Coordinates: 2778453..2778707 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL96_RS12275 (LGL96_12275)	2773785..2774375	-	591	WP_005975525.1	DnaA initiator-associating protein DiaA	-
LGL96_RS12280 (LGL96_12280)	2774564..2774920	-	357	WP_039279491.1	YraN family protein	-
LGL96_RS12285 (LGL96_12285)	2774917..2776935	-	2019	WP_225586410.1	penicillin-binding protein activator	-
LGL96_RS12290 (LGL96_12290)	2776997..2777884	+	888	WP_039507283.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
LGL96_RS12300 (LGL96_12300)	2778453..2778707	+	255	WP_039524245.1	plasmid stabilization protein	Antitoxin
LGL96_RS12305 (LGL96_12305)	2778697..2778984	+	288	WP_039282785.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGL96_RS12310 (LGL96_12310)	2779161..2779946	+	786	WP_105879900.1	4,5-DOPA dioxygenase extradiol	-
LGL96_RS12315 (LGL96_12315)	2780133..2781293	-	1161	WP_180783647.1	glutathionylspermidine synthase family protein	-
LGL96_RS12320 (LGL96_12320)	2781304..2781978	-	675	WP_103861630.1	DUF1190 family protein	-
LGL96_RS12325 (LGL96_12325)	2782245..2783639	-	1395	WP_103861629.1	outer membrane channel protein TolC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11011.96 Da
• Isoelectric Point: 10.7694

>T219101 WP_039282785.1 NZ_CP084656:2778697-2778984 [Pectobacterium versatile]
MTYKLKFVPSAMKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQIYSDTKGRSA

Nucleotide

• Length: 288 bp

>T219101 NZ_CP116181:1892422-1892676 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9220.44 Da
• Isoelectric Point: 3.7947

>AT219101 WP_039524245.1 NZ_CP084656:2778453-2778707 [Pectobacterium versatile]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRIVDDRMSELADAEEIS
LDDL

Nucleotide

• Length: 255 bp

>AT219101 NZ_CP116181:1892174-1892425 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A086EVU3