Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 2615861..2616478 | Replicon | chromosome |
Accession | NZ_CP084656 | ||
Organism | Pectobacterium versatile strain SR1 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | C6DHN3 |
Locus tag | LGL96_RS11545 | Protein ID | WP_010281507.1 |
Coordinates | 2616299..2616478 (-) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A426IL41 |
Locus tag | LGL96_RS11540 | Protein ID | WP_039545938.1 |
Coordinates | 2615861..2616271 (-) | Length | 137 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LGL96_RS11525 (LGL96_11525) | 2611725..2612768 | - | 1044 | WP_010299291.1 | DNA-binding transcriptional regulator CytR | - |
LGL96_RS11530 (LGL96_11530) | 2613078..2615276 | - | 2199 | WP_039474910.1 | primosomal protein N' | - |
LGL96_RS11535 (LGL96_11535) | 2615548..2615763 | + | 216 | WP_010281510.1 | 50S ribosomal protein L31 | - |
LGL96_RS11540 (LGL96_11540) | 2615861..2616271 | - | 411 | WP_039545938.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
LGL96_RS11545 (LGL96_11545) | 2616299..2616478 | - | 180 | WP_010281507.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
LGL96_RS11550 (LGL96_11550) | 2616578..2617588 | - | 1011 | WP_039545936.1 | iron ABC transporter permease | - |
LGL96_RS11555 (LGL96_11555) | 2617585..2618547 | - | 963 | WP_039545934.1 | ABC transporter substrate-binding protein | - |
LGL96_RS11560 (LGL96_11560) | 2618557..2619354 | - | 798 | WP_103943591.1 | ABC transporter ATP-binding protein | - |
LGL96_RS11565 (LGL96_11565) | 2619578..2619895 | - | 318 | WP_005973355.1 | met regulon transcriptional regulator MetJ | - |
LGL96_RS11570 (LGL96_11570) | 2620083..2621243 | + | 1161 | WP_010299271.1 | cystathionine gamma-synthase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6560.69 Da Isoelectric Point: 10.7838
>T219100 WP_010281507.1 NZ_CP084656:c2616478-2616299 [Pectobacterium versatile]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI
Download Length: 180 bp
>T219100 NZ_CP116181:1892174-1892425 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 137 a.a. Molecular weight: 14533.41 Da Isoelectric Point: 4.3391
>AT219100 WP_039545938.1 NZ_CP084656:c2616271-2615861 [Pectobacterium versatile]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR
Download Length: 411 bp
>AT219100 NZ_CP116181:1892422-1892676 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7W2I1S0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A426IL41 |