Detailed information of TA system TA021910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 3164670..3165363
• Replicon: chromosome
• Accession: NC_008781
• Organism: Polaromonas naphthalenivorans CJ2

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A1VRL9
• Locus tag: PNAP_RS14995
• Protein ID: WP_011802369.1
• Coordinates: 3164670..3165047 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: A1VRM0
• Locus tag: PNAP_RS15000
• Protein ID: WP_011802370.1
• Coordinates: 3165028..3165363 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PNAP_RS14970	3159980..3160666	-	687	WP_041377320.1	DnaA regulatory inactivator Hda	-
PNAP_RS14975	3160968..3162005	+	1038	WP_011802367.1	phosphoribosylformylglycinamidine cyclo-ligase	-
PNAP_RS14980	3162440..3162856	+	417	WP_011802368.1	hypothetical protein	-
PNAP_RS25755	3162881..3164013	+	1133	WP_086000545.1	IS630 family transposase	-
PNAP_RS27075	3164053..3164259	+	207	WP_157040300.1	hypothetical protein	-
PNAP_RS14995	3164670..3165047	+	378	WP_011802369.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PNAP_RS15000	3165028..3165363	+	336	WP_011802370.1	helix-turn-helix domain-containing protein	Antitoxin
PNAP_RS15005	3165551..3166744	+	1194	WP_011802371.1	MFS transporter	-
PNAP_RS15010	3166952..3167506	+	555	WP_041376739.1	isochorismatase family protein	-
PNAP_RS15015	3167503..3168513	+	1011	WP_011802373.1	helix-turn-helix domain-containing protein	-
PNAP_RS15020	3168561..3169412	-	852	WP_011802374.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-93)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13843.96 Da
• Isoelectric Point: 9.5536

>T21910 WP_011802369.1 NC_008781:3164670-3165047 [Polaromonas naphthalenivorans CJ2]
MPSNEKPLEWIGSSHKDLMTLPADVRRFFGFALSLAQAGDRHDAAKVLKGFGGAGVLEVVEDDVGGTYRAVYTVKFAQAV
FVLHCFQKKSKRGIATPKEEMDIIHARLKVAEAFAKELRNEKTTH

Nucleotide

• Length: 378 bp

>T21910 NC_008781:3164670-3165047 [Polaromonas naphthalenivorans CJ2]
ATGCCCAGTAACGAAAAACCGCTCGAATGGATCGGCAGCAGCCACAAGGACTTGATGACACTGCCAGCGGATGTACGGCG
GTTTTTCGGTTTTGCCTTGTCATTGGCACAAGCCGGTGATCGGCACGACGCGGCCAAGGTGCTCAAAGGCTTTGGTGGTG
CCGGGGTTCTTGAGGTGGTGGAAGACGATGTTGGCGGCACCTACCGCGCCGTGTACACCGTGAAGTTTGCACAAGCAGTG
TTCGTCCTCCACTGCTTCCAGAAGAAAAGCAAGCGCGGCATTGCCACGCCAAAGGAAGAGATGGACATTATTCACGCTAG
GCTCAAAGTGGCTGAGGCATTTGCAAAGGAGTTGCGAAATGAAAAAACGACTCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12096.29 Da
• Isoelectric Point: 10.3605

>AT21910 WP_011802370.1 NC_008781:3165028-3165363 [Polaromonas naphthalenivorans CJ2]
MKKRLIDGIEVQQGSGNVYADLGLPDAEKLKIKTGLVIEIRKAMRSLGLTQQEAAKRMGITQPKVSGMMRGDFANLSERK
LMDCLTRLGYDIEISVRPAKAALGHLVLASA

Nucleotide

• Length: 336 bp

>AT21910 NC_008781:3165028-3165363 [Polaromonas naphthalenivorans CJ2]
ATGAAAAAACGACTCATTGACGGGATCGAAGTACAACAGGGTTCGGGCAACGTCTATGCCGATCTGGGTCTGCCAGACGC
GGAAAAGCTCAAGATCAAAACCGGCTTGGTGATCGAAATCAGAAAAGCCATGCGCAGCCTTGGCCTGACGCAGCAAGAAG
CGGCCAAGCGCATGGGCATCACTCAACCCAAGGTGTCCGGCATGATGCGCGGTGACTTCGCCAACCTTTCGGAGCGCAAG
CTAATGGACTGCCTGACACGGCTGGGCTACGACATCGAGATCAGCGTGCGCCCCGCCAAGGCAGCGCTTGGGCATCTGGT
GCTTGCCTCTGCGTAA

Structures

Toxin

• AlphaFold DB: A1VRL9

Antitoxin

• AlphaFold DB: A1VRM0