Detailed information of TA system TA219099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2567831..2568465
• Replicon: chromosome
• Accession: NZ_CP084656
• Organism: Pectobacterium versatile strain SR1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LGL96_RS11350
• Protein ID: WP_103971408.1
• Coordinates: 2567831..2568106 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A221T3Z5
• Locus tag: LGL96_RS11355
• Protein ID: WP_010308714.1
• Coordinates: 2568103..2568465 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL96_RS11335 (LGL96_11335)	2564857..2566227	-	1371	WP_107333599.1	envelope stress sensor histidine kinase CpxA	-
LGL96_RS11340 (LGL96_11340)	2566224..2566922	-	699	WP_010308725.1	envelope stress response regulator transcription factor CpxR	-
LGL96_RS11345 (LGL96_11345)	2567076..2567600	+	525	WP_103862316.1	cell-envelope stress modulator CpxP	-
LGL96_RS11350 (LGL96_11350)	2567831..2568106	+	276	WP_103971408.1	type II toxin-antitoxin system HicA family toxin	Toxin
LGL96_RS11355 (LGL96_11355)	2568103..2568465	+	363	WP_010308714.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LGL96_RS11360 (LGL96_11360)	2568725..2572468	+	3744	WP_225586630.1	DUF4132 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-85)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10020.63 Da
• Isoelectric Point: 11.1875

>T219099 WP_103971408.1 NZ_CP084656:2567831-2568106 [Pectobacterium versatile]
MQGKIASLRKKQRETLSHIFKTPILSGVKWSSIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T219099 NZ_CP116181:969416-969823 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13495.29 Da
• Isoelectric Point: 4.6225

>AT219099 WP_010308714.1 NZ_CP084656:2568103-2568465 [Pectobacterium versatile]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERHISVNTFIVETLSEHLKQA

Nucleotide

• Length: 363 bp

>AT219099 NZ_CP116181:969169-969435 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A221T3Z5