Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2398917..2400460 Replicon chromosome
Accession NZ_CP084656
Organism Pectobacterium versatile strain SR1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LGL96_RS10620 Protein ID WP_225586443.1
Coordinates 2399183..2400460 (+) Length 426 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LGL96_RS10615 Protein ID WP_039475230.1
Coordinates 2398917..2399183 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL96_RS10590 (LGL96_10590) 2394550..2396052 - 1503 WP_225586444.1 MFS transporter -
LGL96_RS10595 (LGL96_10595) 2396156..2396710 + 555 WP_039475220.1 TetR/AcrR family transcriptional regulator -
LGL96_RS10600 (LGL96_10600) 2396760..2397170 - 411 WP_198997731.1 helix-turn-helix domain-containing protein -
LGL96_RS10605 (LGL96_10605) 2397285..2398136 + 852 WP_198997730.1 SDR family oxidoreductase -
LGL96_RS10610 (LGL96_10610) 2398193..2398756 - 564 WP_198997729.1 hypothetical protein -
LGL96_RS10615 (LGL96_10615) 2398917..2399183 + 267 WP_039475230.1 helix-turn-helix domain-containing protein Antitoxin
LGL96_RS10620 (LGL96_10620) 2399183..2400460 + 1278 WP_225586443.1 type II toxin-antitoxin system HipA family toxin Toxin
LGL96_RS10625 (LGL96_10625) 2400617..2401981 - 1365 WP_225586442.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
LGL96_RS10630 (LGL96_10630) 2402111..2403745 - 1635 WP_039485128.1 membrane protein insertase YidC -
LGL96_RS10635 (LGL96_10635) 2403748..2404005 - 258 WP_010302384.1 membrane protein insertion efficiency factor YidD -
LGL96_RS10640 (LGL96_10640) 2403969..2404328 - 360 WP_010302382.1 ribonuclease P protein component -
LGL96_RS10645 (LGL96_10645) 2404347..2404487 - 141 WP_005976668.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-388)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 47798.77 Da        Isoelectric Point: 6.3157

>T219098 WP_225586443.1 NZ_CP084656:2399183-2400460 [Pectobacterium versatile]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARYH
TDSTQPFDLLAKVGQDSVGALQLVPQGSPVHDIKKIEYKTLSEQQLENILTGYLYDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMIKAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILAEFAQTVDNVITTVGSQLPVD
FPTHISEAILTGLLARSRRLMSGWE

Download         Length: 1278 bp

>T219098 NZ_CP116181:c824453-824076 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9917.18 Da        Isoelectric Point: 9.7281

>AT219098 WP_039475230.1 NZ_CP084656:2398917-2399183 [Pectobacterium versatile]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEASV
ASSWKEEW

Download         Length: 267 bp

>AT219098 NZ_CP116181:c824910-824542 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References